Department of Pharmacology Seminar Series 2022-10-14 12:30: Power to the protein: analyse, signal and protect with bacterial superglues (Professor Mark Howarth, University of Cambridge) 2022-10-21 16:00: Translating Proteostasis Mechanisms to Therapeutics of Diseases of Protein Conformation and Aging (Prof Rick Morimoto, Department of Molecular Biophysics, Northwestern University, US) 2022-10-28 12:30: Engineering insights into the strange world of cancer (Dr Shiladitya Sengupta, Harvard Medical School, US) 2023-01-27 12:30: Pharmaceutical nanotechnology and the control of in vivo drug transport (Prof Ijeoma Florence Uchegbu University College London ) 2023-02-03 12:30: Aurora kinase A: from basic biology to PROTAC-mediated Targeted Protein Degradation (Speaker to be confirmed) 2023-02-10 12:30: The Pharmacology of Pain (Dr Kirsty Bannister King’s College London ) 2023-02-17 12:30: Endogenous and immunological mechanisms of musculoskeletal pain (Dr Shafaq Sikander Queen Mary University of London ) 2023-02-24 12:30: ANNUAL DAVID JAMES SEMINAR DNA graffiti: Mutation patterns in human DNA and how to use them in medicine (Prof Serena Nik-Zainal Academic Dept of Medical Genetics, University of Cambridge ) 2023-03-03 12:30: How PROTACs work: why the ternary complex matters and how it impacts degrader design (Prof Alessio Ciulli School of Life Sciences, University of Dundee ) 2023-03-10 01:00: The structural polymorphism of alpha-synuclein in conditions resembling the cellular environment (Post doc: Dr Maria Zacharopoulou (Itzhaki Lab) Department of Pharmacology, University of Cambridge ) 2023-03-10 12:30: Dysregulation of ADAM10 Shedding activity in naked mole-rat fibroblasts is due to deficient phosphatidylserine externalisation (Post doc: Dr Paulina Urriola Munoz (Smith Lab) Department of Pharmacology, University of Cambridge ) 2023-03-24 12:30: Gender equality in academia: why and how (Prof Paul Walton Dept of Chemistry, University of York ) 2023-10-13 12:30: Third-generation approaches of antibody discovery and optimisation (Dr Pietro Sormanni, Department of Chemistry, University of Cambridge) 2023-10-20 12:30: Exploiting nuclear envelope dysfunction in progeria to identify new therapeutic targets for ageing (Dr Delphine Larrieu, Department of Pharmacology, University of Cambridge) 2023-10-27 12:30: Title to be Confirmed (Dr Alastair Brown, Heptares, Cambridge) 2023-11-03 12:30: GABA-A receptor subtypes controlling pain and itch (Professor Hanns Ulrich Zeilhofer, Department of Chemistry and Applied Bioscience, ETH Zürich) 2023-11-10 12:30: Implications and molecular mechanisms of MOK, a new signaling kinase in neurodegenerative neuroinflammation (Dr Cintia Roodveldt University of Seville ) 2023-11-17 12:30: A novel mechanism of selective inhibition of Glycine receptors observed by Cryo-EM | Controlling and combining signal activation for adhesion and receptor bridging (Speaker to be confirmed) 2023-11-24 12:30: Engineering post-translational regulation of ion channels: basic mechanisms to translation (Professor Henry Colecraft, University of Columbia) 2024-01-26 16:00: Why it’s important to think about equity, diversity and inclusion when designing, running, analysing and reporting clinical trials (Professor Shaun Treweek University of Aberdeen, Health Services Research) 2024-02-02 16:00: Biophysical methods in small molecule drug discovery (Dr Stanislava Panova, Astex Pharmaceuticals, Senior Research Associate) 2024-02-09 16:00: Not just an affair of the heart: A look at ERG channels and Kv7 channels in (Professor Iain Greenwood, St George’s University, Department of Life and Environmental Science) 2024-02-16 16:00: StaRs™ and Structures – a door to the GPCR pharmacological and drug discovery universe (Dr Alastair Brown, Sosei Heptares, Translational Biosciences) 2024-02-23 16:00: David James Seminar: Molecular mechanisms regulating human weight regulation (Professor Sadaf Farooqi PhD, FRCP, FMedSci, FRS, University of Cambridge, Department of Clinical Biochemistry Abstract) 2024-03-01 16:00: A novel type of proteasome condensates that can target toxic protein aggregates (Dr Yu Ye, Imperial College London, Department of Brain Science) 2024-03-08 16:00: PDRA Talks: Nuclear envelope integrity in health and disease | A role for the proton (Dr Anne Janssen, Dr Luke Pattison, University of Cambridge, Department of Pharmacology) 2024-03-15 16:00: Molecular insights into GABA-A receptor pharmacology (Dr Paul Miller, University of Cambridge, Department of Pharmacology) 2024-10-18 16:00: Not too big and not too small – Bicycle peptides for precision targeted therapies (Dr Liuhong Chen, Bicycle Therapeutics) 2024-11-01 16:00: Computational Microbiology of the E. coli cell envelope (Professor Syma Khalid, University of Oxford) 2024-11-08 16:00: Harnessing the principles of cellular resilience for therapeutics (Dr Ritwick Sawarkar, MRC Toxicology, University of Cambridge) 2024-11-15 16:00: Delaying and Measuring ageing (Dr Ivana Bjedov, University College London Cancer Institute) 2024-11-22 16:00: Redirecting innate immune mechanisms against aggregated proteins (Dr William McEwan, University of Cambridge UK Dementia Research Institute) 2024-11-29 16:00: Postdoctoral Researcher Talks (Dr Javier Aguilera Lizarraga, Dr Anwit Pandit) 2025-01-21 16:00: Pharmacology Seminar Series: Title TBC (Speaker to be confirmed) 2025-01-31 16:00: Pharmacology Seminar Series: Human Pain Genetics (Geoff Woods, Cambridge Institute for Medical Research) 2025-02-03 15:00: Pharmacology Seminar Series: Lipid Nanoparticles that Enable the COVID-19 mRNA vaccines and Gene Therapies (Pieter Cullis, Biochemistry and Molecular Biology, Faculty of Medicine, UBC) 2025-02-14 16:00: Pharmacology Seminar Series: Developing More Effective Pharmacological Treatments for Chronic Pain (David Hughes, University of Glasgow) 2025-02-21 16:00: Pharmacology Seminar Series:Dr Alecia-Jane Twigger, Milk it! The Cambridge Lactation Lab Vision (Alecia-Jane Twigger, Cambridge Lactation Lab) 2025-02-28 16:00: Pharmacology Postdoctoral Researcher Talks (Speaker to be confirmed) 2025-03-05 15:00: David James Seminar: Dr Feng Zhang - Exploration of Biological Diversity (Zhang, MIT) 2025-03-07 16:00: Pharmacology Seminar Series: Dr Florian Merkle, Drug Discovery, Action, and Repurposing in iPSC-derived Neurons (Florian Merkle, Department of Pharmacology, University of Cambridge) 2025-05-14 15:00: Structural characterisation of Trypanosoma cruzi antigens for diagnostic and therapeutic applications (Ivan Campeotto, Assistant Professor in Microbial Biotechnology) 2025-10-10 13:00: Pharmacology Seminar Series: Tuomas Knowles, Protein Phase Transitions (Tuomas Knowles, University of Cambridge) 2025-10-17 13:00: Pharmacology Seminar Series: Sarah Teichmann, Translating the Human Cell Atlas (Sarah Teichmann, Cambridge Stem Cell Institute) 2025-10-24 13:00: Pharmacology Seminar Series: David Hodson, Interrogating GPCRs from the Single Molecule to the Whole Animal (David Hodson, University of Oxford) 2025-10-31 13:00: Pharmacology Seminar Series: Natalie Krahmer, Elucidating the Cell Architecture of Metabolic Liver Disease via Spatial Proteomics (Natalie Krahmer, Helmholtz Diabetes Center ) 2025-11-21 13:00: Pharmacology Seminar Series: Helen Walden, Understanding Parkin’s E3 Ligase Activity (Helen Walden, University of Glasgow) 2025-11-28 13:00: Pharmacology Seminar Series: Nikita Gamper, Peripheral Gate in Somatosensory System (Nikita Gamper, School of Biomedical Sciences, University of Leeds) 2025-12-05 13:00: Pharmacology Seminar Series: Hugh Robinson, Ion Channels, Electrical Activity and Energy Consumption in Neuroendocrine Cancer Cells (Hugh Robinson, PDN) 2026-01-09 13:00: Pharmacology Seminar Series: Research Culture Talk: Corinna Alberg and Sara Pensa (Cambridge Africa) and Lucy Woolhouse (Library) (Corinna Alberg and Sara Pensa (Cambridge Africa) and Lucy Woolhouse (Library)) 2026-01-16 13:00: Department of Pharmacology: David James Lecture 2026, Prof Lotte Bjerre Knudsen (Professor Lotte Bjerre Knudsen, Head of IDEA and Chief Scientific Advisor at Novo Nordisk) 2026-01-23 13:00: Pharmacology Seminar Series: Professor Meritxell Canals Buj, Pharmacology, signalling and regulation of the mu-opioid receptor (Professor Meritxell Canals Buj) 2026-01-30 13:00: Pharmacology Seminar Series: Dr Evangelia Petsalaki, From data towards Digital Twins of biological systems: Network-based approaches to study context-specific cell signalling (Speaker to be confirmed) 2026-02-06 13:00: Pharmacology Seminar Series: Professor Clare Bryant, Pattern Recognition Receptor signalling in infection and sterile inflammation (Professor Clare Bryant) 2026-02-13 13:00: Pharmacology Seminar Series: Professor David Ron, How is Endoplasmic Reticulum Stress Recognised? (Professor David Ron) 2026-02-20 13:00: Pharmacology Seminar Series: Professor David Shorthouse, AI (and robots!) for Accelerated Discovery in Pharmaceutical Science (Professor David Shorthouse) 2026-02-27 13:00: Pharmacology Seminar Series: Dr Elle McDonagh, Variant interpretation at scale for safer and more effective disease treatment (Dr Elle McDonagh) 2026-03-05 12:00: Special Guest Lecture: Professor Bill DeGrado, De Novo Design of Protein Catalysts, Drug-Delivery Vehicles and Nanopores (Professor Bill DeGrado, School of Pharmacy, University of California San Francisco) 2026-03-06 13:00: Pharmacology Seminar Series: Postdoctoral Research Associate Talks, Shanlin Rao | Dalila Boi (Dr Shanlin RaoD, Dr Dalila Boi, Department of Pharmacology) 2026-03-13 13:00: Pharmacology Seminar Series: Research Culture: Professor Yeun Joon Kim, Culture Creation and Change in Medical Institutions: Stage 1 Findings at IMS-MRL (Professor Yeun Joon Kim, JBS) 2026-03-27 13:00: Pharmacology Seminar Series: Professor Gopal Sapkota, Induced-proximity approaches for targeted protein degradation and dephosphorylation (Professor Gopal Sapkota)