Biophysical Colloquia 2010-10-06 10:30: Membrane activation of the adaptor complex AP2 in clathrin-mediated endocytosis (Dr. Phil Evans MRC Laboratory of Molecular Biology) 2010-10-13 10:30: From conformational chaos to robust regulation: the structure and function of a multi-enzyme machine from RNA metabolism ( Prof. Ben Luisi Department of Biochemistry, University of Cambridge) 2010-10-20 10:30: Molecular Biological and Molecular Genetic studies of the Mechanisms Underlying Neurodegeneration in Alzheimer's Disease (Prof. Peter Hyslop Cambridge Institute for Medical Research) 2010-10-27 10:30: Skeletal diversity in sesquiterpenes from the perspective of a cyclizing carbocation (Dr. Paul O'maille John Innes centre, Norwich, UK) 2010-11-03 10:30: Host matrix-pathogen interactions and redox sensing; tandem beta-zippers and "inside-out" protein-protein recognition. ( Dr. Jennifer Potts University of York) 2010-11-10 10:30: Aminoacyl-tRNA synthetases: Possible Origins and Molecular Mechanisms Leading to the Evolution of Enhanced Catalytic Activity, Specificity, and Allostery (Dr. Charles Carter University of North Carolina, NC, USA) 2010-11-17 10:30: From coarse-grained models of fibril formation to atomistic details of potential inhibitors (Prof. Amedeo Caflisch Department of Biochemistry, the University of Zurich, Zurich, Switzerland) 2010-11-24 10:30: Designing protein polymerases for unnatural nucleic acids (Vitor Pinheiro MRC Laboratory of Molecular Biology) 2010-12-01 10:30: Structural Ensembles of Small Peptides - An NMR Perspective (Dr. Stephan Schwarzinger Institute of Biopolymers, University of Bayreuth, Germany) 2011-01-26 10:30: Title to be confirmed (Dr. Robert Best, University of Cambridge.) 2011-02-02 10:30: Title to be confirmed (Andras Malnasi-Csizmadia, Department of Biochemistry Eötvös University, Budapest) 2011-02-09 10:30: Structural insights into the initiation of DNA synthesis in eukaryotic replication (Dr. Luca Pellegrini, Department of BIochemistry, University of Cambridge) 2011-02-14 10:30: Title to be confirmed (Andreas Ramos, NIMR, London) 2011-02-16 10:30: Applications of single molecule fluorescence to biology (Prof. David Klenerman, Department of Chemistry, University of Cambridge) 2011-02-23 10:30: Title to be confirmed (Fabio Falsone, University of Graz, Austria) 2011-03-02 10:30: Quality control in the IgM factory: the many roles of ERp44 (Roberto Sitia, San Raffaele Hospital, MILAN) 2011-03-09 10:30: TBC (Nobu Tokuriki, Department of Chemistry, University of Cambridge.) 2011-03-16 10:30: Modular protein-nucleic acid interactions in the FBP family (Andres Ramos, NIMR MRC) 2011-03-22 10:30: Creating novel proteins by selection and design (Lynne Regan, Yale University) 2011-04-08 01:00: Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity ( Abel Garcia-Pino,University of Brussels, Belgium) 2011-06-01 10:30: Manipulating protein aggregation in the nervous system (Prof Michael Cheetham, Division of Molecular and Cellular Neuroscience, UCL) 2011-06-08 10:30: Key macromolecules in bacterial infections: a structural perspective (Dr. Rita Berisio, Institute of Biostructures and Bioimaging, Italian National Research Council.)