Biochemistry Seminar Room, Sanger Building


2011-12-06 16:00: FKBP - a structure without a cause? (Christian Edlich (EDL))

2011-12-06 16:00: Model interaction systems in the search for inhibitors of protein-protein interactions (Sandra Greive (MH))

2012-01-10 16:00: A Study of the Human Primase: Initiator of DNA Replication (Mairi Kilkenny (LP))

2012-01-10 16:00: Relating structure to function in natural surfactant proteins. (Steve Vance (RWB))

2012-06-12 16:00: Crystal Structure of Folliculin Uncovers a HiDENN Function (Ravi Nookala (TLB Group))

2012-09-18 16:00: The Structures of Whole Chromosomes in Individual Cells (Tim Stevens (EDL Group))

2013-10-23 10:15: Crystallisation and structure of respiratory complex I, a giant molecular proton pump (Leonid Sazanov, MRC Mitochondrial Biology Unit, Wellcome Trust / MRC Building, cambridge)

2013-10-30 10:15: Evolution & dynamics of protein complexes (Sarah Teichmann, Wellcome Trust Sanger Institute)

2013-11-06 10:15: Title to be confirmed (Shaoxia Chen, MRC-LMB, cambridge)

2013-11-13 10:15: Chirality as a crossroad of chemistry and biology (Professor Reiko KURODA, Tokyo University of Science (Japan))

2013-11-27 10:15: Protein-Protein Interaction Networks and Diseases (Franca Fraternali, Randall Division of Cell and Molecular Biophysics, King's College London, UK )

2013-11-27 10:15: Analysis of allosteric communication and functional local motions using a Structural Alphabe (Alessandro Pandini,Randall Division of Cell and Molecular Biophysics,King's College London, UK  )

2014-01-22 10:15: Using evolutionary sequence variation to make inferences about protein structure and function (Lucy J. Colwell,  Department of Chemistry, University of Cambridge)

2014-01-28 10:15: Title to be confirmed (Paula de Fonseca - LMB)

2014-02-05 10:15: Cyclofluidic: Quick hit-to-lead optimization using an integrated microfluidic approach  (Dr Ronald Dorenbos, Business Development Director Europe Cyclofluidic Ltd.)

2014-02-26 10:15: Small Angle X-ray Scattering: sample preparation, data collection, and data analysis. (Dr Meindert Lamers, MRC-LMB, Cambridge, U.K)

2014-03-26 10:15: Coot's EM Model-fitting Tools (Dr Paul Emsley, MRC-LMB, Cambridge, U.K.)

2014-03-28 10:30: Antiviral innate immunity in Drosophila (Jean-Luc Imler, Université de Strasbourg)

2014-04-02 10:15: The Structure of the Large Subunit of the Yeast Mitochondrial Ribosome (Dr Alan Brown)

2014-04-09 10:15: How insulin binds to the insulin receptor: structural biology and protein engineering (Dr Michael Weiss, School of Medicine Cleveland, USA)

2014-05-28 10:15: Crystal structure of the Drosophila Toll-Spätzle complex reveals neurotrophin-like binding specificity (Monique Gangloff, Biochemistry)

2014-06-11 10:15: Structures and mechanisms of macromolecular complexes involved in transcription and DNA repair (Professor Xiaodong Zhang Imperial College London Department of Life Sciences)

2014-10-15 10:15: Support Science and Diamond Light Source (Carina Lobley, DLS)

2014-10-29 10:15: (1) An introduction to Gene Synthesis - capabilities and uses. (2) An introduction to precise genome editing with TAL effectors and CRISPR (Nikolai Netuschil and Nahush Karnataki. ThermoFisher Scientific)

2014-11-12 10:15: Identification and characterization of interaction sites with MD simulations of mixed solvents – Application to non-standard targets (Professor Xavier Barril, ICREA Research Professor at Barcelona University, Spain)

2015-01-21 10:15: Dr Takashi Ochi and Dr Qian Wu (Dr Takashi Ochi, Department of Biochemistry, University of Cambridge, u. k)

2015-01-28 10:15: Investigating the human proteasome by cryo-EM - an emerging tool for structural based drug design (Dr Paula de Fonseca - MRC LMB)

2015-02-04 10:15: Dr Christian Ottmann, Title to be confirmed (Dr. Christian Ottmann  Associate Professor, (UHD)  Molecular Cell and Structural Biology,  Chemical Biology,  Dpt. of Biomedical Engineering and  Institute for Complex Molecular Systems,  Technische Universiteit,  EINDHOVEN)

2015-02-18 10:15: Dr Isaac Westwood - Title to be Confirmed (Dr Isaac Westwood - Institute of Cancer Research)

2015-04-29 10:15: Recent advances in high resolution cryo-EM structure determination (Xiaochen Bai, LMB-MRC)

2015-05-07 16:30: Biodiversity and Drug Discovery (Professor Glaucius Oliva,  Universidade de São Paulo)

2015-05-13 10:15: Predicting drug-target binding kinetics through enhanced sampling simulations (Professor Francesco Gervasio, Dept. Chemistry, University College London)

2015-05-20 10:15: Structural Mechanisms in Protein Kinase Regulation (Professor John Kuriyan, Berkeley)

2015-06-03 10:15: Impact of rapid whole-genome sequencing on diagnostic and public health microbiology (Dr Claudio U. Köser, Dept. Medicine and Wellcome Trust Genome Campus)

2015-06-17 10:15: Structural Biology and Transmembrane Signalling: Understanding a 'Double-edged' Receptor, DCC (Jia-Huai Wang (Harvard))

2015-06-24 10:15: Title to be confirmed (Dr Dijana Matak-Vinkovic, Dept. Chemistry, Cambridge)

2015-08-26 15:00: Modulating Protein-Protein Interactions (Dr Jessica Holien - St. Vincent's Institute for Medical Research)

2015-09-02 10:15: Atomic resolution cryoEM structure of bacteriophage (Prof. Wah Chiu, Baylor College of Medicine, Texas)

2015-10-21 10:15: ARCIMBOLDO, an ab initio approach to MR phasing (Isabel Uson (Molecular Biology Institute of Barcelona))

2015-10-28 10:15: Migle Kisonaite - "Structure of Gremlin-1: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism" and Xuelu Wang "Understanding of the Pro-domain in TGF-β Superfamily: Structure and Characterisation of Pro-activin A" (Xuelu Wang and Migle Kisonaite - Department of Biochemistry)

2015-11-04 10:15: Fitting atomic structures into EM density maps (Dr Arun Prasad Pandurangan (Department of Biochemistry))

2015-11-18 10:15: Prof Song Tan - TBC (Professor Song Tan (Penn State University))

2015-11-25 10:15: Dr Paul Brear - Inhibiting CK2α from outside the active site (Paul Brear - Department of Biochemistry)

2015-12-02 10:15: Mapping of ligand binding site and activation mechanism of APJ receptor (Prashant Kumar (Department of Biochemistry))

2015-12-16 10:15: Computational approaches to investigate protein-nucleic acid and protein-protein interactions (Dr Sony Malhotra (Department of Biochemistry))

2016-01-20 10:15: Protein transport to the endoplasmic reticulum (Dr Rebecca Voorhees (LMB))

2016-03-02 10:15: Pregnancy outcome prediction using placenta epigenetic data (Dr Sung Gong (Clinical School of Medicine))

2016-04-27 14:00: The E. coli replisome caught in the act by cryo-EM and single molecule microscopy (Dr Meindert Lamers (LMB))

2016-05-18 10:15: The 3D structures of genomes in single cells reveal principles of nuclear organization (Dr Tim Stevens (LMB, Cambridge))

2016-05-25 10:15: Matching density maps of macromolecular assemblies from Cryo-EM and assessment of fitted atomic models (Dr Agnel Praveen Joseph)

2016-06-01 10:15: TBC (Dr Owen Davies (Newcastle University))

2016-06-15 10:15: Targeting Trehalose and Methylglucose Lipopolysaccharide Pathways of M. tuberculosis (Nupur Verma (Department of Biochemistry, Cambridge))

2016-07-13 10:15: Predicting the impact of natural and disease variants on protein function (Professor Rob Russell (Heidelberg University))

2016-09-28 10:15: Interactive molecular dynamics for improved model building and exploration in structural biology (Dr Tristan Croll (CIMR, Cambridge))

2016-10-10 15:00: Structure and Function of TIFA - A New Player in Immunity and Cancer (Prof Ming-Daw Tsai (Academia Sinica in Taiwan))

2016-10-26 10:15: A computational framework for optimizing combination drug therapies (Dr Michael Lyons (Colorado State University))

2016-11-16 14:30: Phosphoproteomic strategies reveal global impact of kinase inhibitors on regulatory kinase networks and the phosphoproteome (Prof David Litchfield (University of Western Ontario))

2017-01-25 10:15: What's new at PDBe? (Dr Deepti Gupta and Dr John Berrisford (PDBe))

2017-03-01 10:15: Computational study of mutations in proteins (Professor Douglas Pires (Centro de Pesquisas René Rachou, FIOCRUZ - Minas Gerais, Brazil))

2017-03-08 10:15: Using Integrative Methods in Structural Biology to Understand Protein Structure (Dr Daniel Saltzberg (University of California, San Francisco))

2017-03-29 10:15: COSMIC Catalogue of Cancer Mutations and the 3D Proteome (Simon Forbes & Harry Jubb (Sanger Institute, Wellcome Genome Campus))

2017-04-03 10:15: High-Throughput Fragment-Based Drug Discovery at Diamond Synchrotron: Robots can do much of the work to screen in FBDD! (Prof Frank von Delft (Diamond Light Source / Structural Genomics Consortium - Oxford))

2017-05-10 10:15: Rebuilding the HDX-MS Method to Support Integrative Methods in Structural Biology (Dr David Schriemer (University of Calgary, Alberta))

2017-05-24 10:15: Revolutionary Cryo-EM: the Potential  Power to Visualize High Resolution Dynamic Structures (Dr Kai Zhang (LMB))

2017-05-31 10:15: Linking Structural Biology and Clinical Genomics: Purine Nucleotidase in Relapsed Leukemia (Dr. Aleš Hnízda (Academy of Sciences of the Czech Republic, Prague; From 1st June: Department of Biochemistry, University of Cambridge))

2017-10-11 10:15: Signalling through interleukin/interferon receptors: outside and inside of the cell (Dr. Alexander Wlodawer (Chief, Macromolecular Crystallography Laboratory, NCI-Frederick))

2017-12-13 10:15: The simple reason that M. avium subspecies paratuberculosis has been missed as a major human pathogen is that, unknowingly, it's been treated since 1942 (Dr Robert Greenstein (VA Medical Center, Bronx, NY))

2018-01-24 10:30: Human 2-oxoacid-dependent Oxygenases (Dr M. S. Islam (Department of Biochemistry, University of Cambridge))

2018-02-26 10:15: Shortening Tuberculosis Chemotherapies: Elucidating the Molecular genetic programs of persistence of M. tuberculosis (Professor W. Jacobs, Howard Hughes Medical Institute, NY)

2018-03-07 10:15: Mycobacterium Tuberculosis Physiology: The Intricate Interplay between Drug Tolerance and Drug Resistance (Caroline Pule (Faculty of Medicine, Stellenbosch University, South Africa))

2018-03-19 10:15: Not Too Big - Not Too Small: Fragment Antibody Drug Candidates as Alternatives to Antibodies for Solid Tumours (Dr Gokhan Yahioglu (Director of Medicinal Chemistry, Antikor Biopharma Ltd))

2018-03-21 10:30: Using Computational Structure Biology to Study Diseases that cause Major Health Concerns in Brazil (Dr Pedro Torres)

2018-03-28 10:15: Toward the Reconstitution of the Maturation of Okazaki Fragments Multiprotein Complex in Human at the Single Molecule Level (Dr Luay Joudeh (Pellegrini Group))