Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery


2007-10-19 15:00: The long and the short: virulence proteins from Staphylococcus and Streptococcus (Professor Ted Baker, Director, Centre for Molecular Biodiscovery)

2007-11-02 14:15: Structural basis of fatty acid synthesis  catalyzed by giant multienzyme complexes (Dr Nenad Ban, Professor of Structural Molecular Biology, ETH Zurich, Swiss Federal Institute of Technology)

2007-11-05 09:00: UCB Approaches to Drug Discovery, A Focus on 2 Cambridge projects (Dr Will Pitt, UCB Celltech)

2007-11-08 11:00: New protein purification columns and media from  GE Healthcare (Penny Hamlyn, GE Healthcare)

2007-11-14 12:00: Paradoxical Features of Nicotinic Receptor (Professor Stuart Edelstein, University of Geneva)

2007-12-03 09:00: Fragment based drug discovery - from crystal to clinic (Dr David Rees, Astex Therapeutics)

2008-03-03 09:00: Expriences in Structure-based  Discovery (Prof Rod Hubbard, Vernalis and University of York)

2008-03-14 12:00: High intrinsic binding specificity mediates the interactions of a yeast SH3 domain (Dr. Elliott Stollar, Program in Molecular Structure and Function, Hospital for Sick Children, Toronto)

2008-03-28 10:30: Toll like receptors - Investigating innate immunity and infection (Dr Kathy Triantafilou, Infection and immunity Group, University of Sussex)

2008-04-07 13:00: Mechanisms of Transmembrane Transport: towards structures of membrane protein drug targets (Professor Robert Stroud, University of California, San Francisco)

2008-04-09 12:00: DNA site-specific recombination: Architecture of a recombinase (Professor Marshall Stark University of Glasgow)

2008-05-12 13:00: Structural chemistry in the pharmaceutical industry: view from a returned exile (Dr Nic Harmer, University of Exeter)

2008-06-26 11:30: Small hydrogen-bonded motifs in proteins and their significance for amyloid formation (James Milner-White, University of Glasgow)

2008-07-18 10:30: Neurotrophic factors in Drosophila (Dr Alicia Hidalgo, University of Birmingham)

2008-08-14 10:30: test (Speaker to be confirmed)

2008-10-08 11:00: Convergence of Molecular Epidemiology, Functional Biology and Host-pathogen Interactions: Zeroing on Potential Drug Targets for M. TUBERCULOSIS (Professor Seyed E. Hasnain, Vice-Chancellor University of Hyderabad)

2008-10-10 13:00: Molecular Puzzles: Learning About Function and Mechanism of Enzymes From their Structures (Dr. Alex Wlodawer, Macromolecular Crystallography Laboratory, National Cancer Institute Frederick)

2008-10-12 11:15: Fragment-based Screening and It's Role in Ontario Cancer Institute (Prof Nickolay Chirgadze, Department of Pharmacology and Toxicology, University of Toronto)

2008-10-24 15:00: Party for Richard and Timo (All welcome!)

2008-11-12 10:15: Pathway-based analysis of genome-wide siRNA screens (Dr. Miguel Camargo, Merck, Boston USA)

2008-11-19 16:00: Expression systems for protein complexes ( Dr Imre Berger, EMBL, Heidelberg)

2008-12-03 16:00: Biocore (Speaker to be confirmed)

2008-12-04 13:00: SPR - theory and practise (Dr Joe Maman)

2008-12-05 17:30: Leaving drinks for Sheena (Dr Sheena D'Arcy)

2008-12-15 11:00: Recent adventures in protein folding and design (Professor Lynne Regan, Yale University)

2009-01-28 10:15: Conventional and non-conventional methods of protein crystal growth (Professor Abel Moreno)

2009-02-04 10:15: Protein Crystal Growth in Gels and Capillary Tubes (Professor Abel Moreno)

2009-02-11 10:15: The role of impurities in protein crystallisation: advantages and disadvantages (Professor Abel Moreno)

2009-03-04 10:15: The influence of electric and magnetic fields to increase the crystal quality of proteins (Professor Abel Moreno)

2009-03-11 10:00: Public domain medicinal chemistry data at the EBI and the use in drug discovery (Dr John Overington,  Chemogenomics and ChEMBL Databases, European Bioinformatics Institute (EMBL-EBI))

2009-04-01 10:15: Electrochemically-assisted protein crystallisation: Applications to biosensors (Professor Abel Moreno)

2009-06-03 10:15: The microseed matrix screening method for protein crystallisation (Dr May Marsh)

2009-06-11 16:00: HIV-1 Reverse Transcriptase: Structure, Drug Resistance, and Drug Design (Professor Eddy Arnold, Rutgers University)

2009-10-15 11:00: Molecular recognition - from single target to protein complexes (Dr Agata Kranjc Pietrucci from International School of Advanced Studies, Trieste, Italy)

2009-11-16 16:00: Completely in vitro protein engineering automation (Prof Homme Hellinga, Duke University)

2010-01-13 10:15: Recap of Experimental Fragment-based projects (May, Marko, Anja, Anna, Michal, Sachin, Marcio, Leo, Noha)

2010-01-20 10:15: Targetting PPI (Alicia and Narcis Fernandez-Fuentes from the Leeds Institute of Molecular Medine (LIMM))

2010-01-27 10:15: X-ray single soaks or cocktails? Growing versus Linking.  (Round table (Tom and May to lead), Dave Huggins)

2010-02-03 10:15: ITC (Leo and Marko)

2010-02-10 10:15: Fragments versus traditional screening . Off-target analysis (Speaker to be confirmed)

2010-02-17 10:15: Drug-protein Databases: ZINC, Credo, CHEMBL (Will; Adrian)

2010-02-24 10:15: STING_DB ( Dr Goran Neshi, Laboratorio de Biologia Computacional, Cidade Universitária "Zeferino Vaz" , Campinas,  Brazil)

2010-03-10 10:15: Surface Plasmon Resonance (Speaker to be confirmed)

2010-03-17 10:15: Engineering proteins for fragment screening (Speaker to be confirmed)

2010-05-10 11:15: Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY (Dr Ilona Nudelman, Weizmann Institute)

2010-05-19 10:15: Can machines understand the Scientific Literature? (Professor Peter Murray Rust (Unilever Centre, Chemistry, Cambridge))

2010-06-02 10:15: Fragment-based drug discovery using X-ray crystallography. (Dr Anne Cleasby (Astex))

2010-06-16 10:15: Targetting Protein-Protein Interactions: Synergies between NCEs and New Antibodies. (Dr Alastair Lawson (UCB- Celltech))

2010-06-23 10:15: Off-site Targets: Predicting drug polypharmacology using ligand similarity ensembles. (Michael Keiser (UCSF))

2010-06-30 10:15: Using Biacore for fragment screening (Catherine McDonnell, GE Healthcare)

2010-07-07 10:15: Software for fragment linking and growing. (Nikolay Todorov (Molscape))

2010-07-07 10:35: Restraints on Protein Models from NMR Chemical Shifts (Rinaldo Wander Montalvao (Chemistry, Cambridge).)

2010-07-14 10:15: The rational design of small-molecule Neuropilin-1 antagonists (Trevor Perrior, Research Director of Domainex)

2011-01-10 11:30: i-SITE: An energetic approach to predict ligand-binding site on protein surface (Dr Mizuki Morita, Laboratory of Bioinformatics, National Institute of Biomedical Innovation (NIBIO), Japan)

2011-01-12 10:15: The Ghosts of PDBe Past, Present  and Yet to Come (Dr Gerard Kleywegt, PDB Europe, EBI, Hinxton)

2011-01-26 10:15:  Drug Protein Interaction Databases (Adrian Schreyer, Alicia Higueruelo, Will Pitt)

2011-06-15 10:15: Designing Bioactive Molecules and Mode-of-Action Analyses - The Benefits of Learning From the Past. (Dr Andreas Bender, Unilever Centre, Cambridge)

2011-06-22 10:15: Crystal dehydration: Experimental design with a home source and at the synchroton ( Dr Juan Sanchez Weatherby: Diamond, UK)

2011-07-06 11:00: Probing protein-ligand recognition mechanisms with isothermal titration calorimetry (Dr Mark Williams. Birkbeck College)

2011-07-13 10:15:  Receptor-based Drug Discovery ( Dr Jiye Shi, UCB Celltech)

2011-07-27 10:15: Structural complexomics of eukaryotic gene expression. (Dr Imre Berger, EMBL, Grenoble, France)

2011-11-16 10:15: Fuzzy complexes: ambiguity in protein-protein and protein-DNA interactions (Professor Monika Fuxreiter Institute of Enzymology, Budapest, HUNGARY and LMB, MRC, Cambridge, UK)

2011-11-23 10:15: Low resolution refinement tools in the program REFMAC (Dr Garib N Murshudov, LMB, MRC, Cambridge, U.K)

2011-11-24 11:00: Making candy for signal transduction research -  Adventures in Willy Wonka land (Prof Morten Grötli, Department of Chemistry, University of Gothenburg)

2011-11-30 10:15: Low Resolution Crystallography (Dr Dima Chirgadze, Biochemistry Department, University of Cambridge)

2011-12-07 10:15: To be confirmed (Dr Bissan Al-Lazikani, Computational Biology and Chemogenomics Institute of Cancer Research, U.K)

2011-12-21 10:15: Domain swapping in proteins (Dr Sowdhamini, National Centre for Biological Sciences (TIFR) UAS-GKVK Campus Bellary Road Bangalore 560 065 INDIA)

2012-04-25 10:15: SAXS studies on biological molecules at Diamond Light Source (Inoue Katsuaki, DLS, UK)

2012-05-02 10:15: Structural studies of chromosome segregation (Martin Singleton)

2012-06-13 10:15: Title to be confirmed (Helen Saibil)

2012-10-10 10:15: X-ray diffraction data reduction: space group determination, scaling and intensity statistics (Dr Phil Evans, FRS, LMB)

2012-10-24 10:15: The importance of thermostability and its application to the structure determination of GPCRs (Dr Chris Tate, LMB)

2012-11-07 10:15: Identifying hot-spots and designing small molecule inhibitors at protein-protein interfaces: taking advantage of bound water networks (Dr David J. Huggins, Department of Oncology Hutchison/MRC Research Centre)

2012-11-21 10:15: AnchorQuery: Interactive and efficient discovery tool of small molecule protein-protein interaction       antagonists (Carlos Carmachio)

2013-02-13 10:15: OPPF-UK: a national resource centre for protein production. (Dr Louise Bird, OPPF, UK)

2013-02-27 10:15: PHASER workshop (Airlie McCoy, CIMR, University of Cambridge)

2013-03-22 13:00: Open Source Drug Discovery:  Developing a Systems Level Translational Platform for Neglected Diseases (Prof. Samir K. Brahmachari, Founder Director, Institute of Genomics and Integrative Biology,  Director General, Council of Scientific & Industrial Research,  Delhi, India)

2013-03-27 10:15: Probing dynamic conformational changes in lipid signalling using hydrogen deuterium exchangemass spectrometry  (Dr John Burke, LMB, Cambridge U.K)

2013-10-23 10:15: Crystallisation and structure of respiratory complex I, a giant molecular proton pump (Leonid Sazanov, MRC Mitochondrial Biology Unit, Wellcome Trust / MRC Building, cambridge)

2013-10-30 10:15: Evolution & dynamics of protein complexes (Sarah Teichmann, Wellcome Trust Sanger Institute)

2013-11-06 10:15: Title to be confirmed (Shaoxia Chen, MRC-LMB, cambridge)

2013-11-13 10:15: Chirality as a crossroad of chemistry and biology (Professor Reiko KURODA, Tokyo University of Science (Japan))

2013-11-27 10:15: Protein-Protein Interaction Networks and Diseases (Franca Fraternali, Randall Division of Cell and Molecular Biophysics, King's College London, UK )

2013-11-27 10:15: Analysis of allosteric communication and functional local motions using a Structural Alphabe (Alessandro Pandini,Randall Division of Cell and Molecular Biophysics,King's College London, UK  )

2014-01-22 10:15: Using evolutionary sequence variation to make inferences about protein structure and function (Lucy J. Colwell,  Department of Chemistry, University of Cambridge)

2014-01-28 10:15: Title to be confirmed (Paula de Fonseca - LMB)

2014-02-05 10:15: Cyclofluidic: Quick hit-to-lead optimization using an integrated microfluidic approach  (Dr Ronald Dorenbos, Business Development Director Europe Cyclofluidic Ltd.)

2014-02-26 10:15: Small Angle X-ray Scattering: sample preparation, data collection, and data analysis. (Dr Meindert Lamers, MRC-LMB, Cambridge, U.K)

2014-03-26 10:15: Coot's EM Model-fitting Tools (Dr Paul Emsley, MRC-LMB, Cambridge, U.K.)

2014-04-02 10:15: The Structure of the Large Subunit of the Yeast Mitochondrial Ribosome (Dr Alan Brown)

2014-04-09 10:15: How insulin binds to the insulin receptor: structural biology and protein engineering (Dr Michael Weiss, School of Medicine Cleveland, USA)

2014-05-28 10:15: Crystal structure of the Drosophila Toll-Spätzle complex reveals neurotrophin-like binding specificity (Monique Gangloff, Biochemistry)

2014-06-11 10:15: Structures and mechanisms of macromolecular complexes involved in transcription and DNA repair (Professor Xiaodong Zhang Imperial College London Department of Life Sciences)

2014-10-08 10:15: Professor Randy Read - title to be comfirmed (Professor Randy Read, CIMR, Cambridge)

2014-10-15 10:15: Support Science and Diamond Light Source (Carina Lobley, DLS)

2014-10-29 10:15: (1) An introduction to Gene Synthesis - capabilities and uses. (2) An introduction to precise genome editing with TAL effectors and CRISPR (Nikolai Netuschil and Nahush Karnataki. ThermoFisher Scientific)

2014-11-12 10:15: Identification and characterization of interaction sites with MD simulations of mixed solvents – Application to non-standard targets (Professor Xavier Barril, ICREA Research Professor at Barcelona University, Spain)

2014-12-03 11:00: Tools for refinement against low resolution X-ray data and fit to EM reconstructions (Dr Garib Murshudov, LMB, MRC)

2015-01-21 10:15: Dr Takashi Ochi and Dr Qian Wu (Dr Takashi Ochi, Department of Biochemistry, University of Cambridge, u. k)

2015-01-28 10:15: Investigating the human proteasome by cryo-EM - an emerging tool for structural based drug design (Dr Paula de Fonseca - MRC LMB)

2015-02-04 10:15: Dr Christian Ottmann, Title to be confirmed (Dr. Christian Ottmann  Associate Professor, (UHD)  Molecular Cell and Structural Biology,  Chemical Biology,  Dpt. of Biomedical Engineering and  Institute for Complex Molecular Systems,  Technische Universiteit,  EINDHOVEN)

2015-02-18 10:15: Dr Isaac Westwood - Title to be Confirmed (Dr Isaac Westwood - Institute of Cancer Research)

2015-02-25 10:15: Dr Meindert Lamers - Title to be confirmed (Dr Meindert Lamers - LMB)

2015-04-29 10:15: Recent advances in high resolution cryo-EM structure determination (Xiaochen Bai, LMB-MRC)

2015-05-07 16:30: Biodiversity and Drug Discovery (Professor Glaucius Oliva,  Universidade de São Paulo)

2015-05-13 10:15: Predicting drug-target binding kinetics through enhanced sampling simulations (Professor Francesco Gervasio, Dept. Chemistry, University College London)

2015-05-20 10:15: Structural Mechanisms in Protein Kinase Regulation (Professor John Kuriyan, Berkeley)

2015-06-03 10:15: Impact of rapid whole-genome sequencing on diagnostic and public health microbiology (Dr Claudio U. Köser, Dept. Medicine and Wellcome Trust Genome Campus)

2015-06-17 10:15: Structural Biology and Transmembrane Signalling: Understanding a 'Double-edged' Receptor, DCC (Jia-Huai Wang (Harvard))

2015-06-24 10:15: Title to be confirmed (Dr Dijana Matak-Vinkovic, Dept. Chemistry, Cambridge)

2015-08-26 15:00: Modulating Protein-Protein Interactions (Dr Jessica Holien - St. Vincent's Institute for Medical Research)

2015-09-02 10:15: Atomic resolution cryoEM structure of bacteriophage (Prof. Wah Chiu, Baylor College of Medicine, Texas)

2015-10-21 10:15: ARCIMBOLDO, an ab initio approach to MR phasing (Isabel Uson (Molecular Biology Institute of Barcelona))

2015-10-28 10:15: Migle Kisonaite - "Structure of Gremlin-1: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism" and Xuelu Wang "Understanding of the Pro-domain in TGF-β Superfamily: Structure and Characterisation of Pro-activin A" (Xuelu Wang and Migle Kisonaite - Department of Biochemistry)

2015-11-04 10:15: Fitting atomic structures into EM density maps (Dr Arun Prasad Pandurangan (Department of Biochemistry))

2015-11-18 10:15: Prof Song Tan - TBC (Professor Song Tan (Penn State University))

2015-11-25 10:15: Dr Paul Brear - Inhibiting CK2α from outside the active site (Paul Brear - Department of Biochemistry)

2015-12-02 10:15: Mapping of ligand binding site and activation mechanism of APJ receptor (Prashant Kumar (Department of Biochemistry))

2015-12-16 10:15: Computational approaches to investigate protein-nucleic acid and protein-protein interactions (Dr Sony Malhotra (Department of Biochemistry))

2016-01-20 10:15: Protein transport to the endoplasmic reticulum (Dr Rebecca Voorhees (LMB))

2016-03-02 10:15: Pregnancy outcome prediction using placenta epigenetic data (Dr Sung Gong (Clinical School of Medicine))

2016-04-27 14:00: The E. coli replisome caught in the act by cryo-EM and single molecule microscopy (Dr Meindert Lamers (LMB))

2016-05-18 10:15: The 3D structures of genomes in single cells reveal principles of nuclear organization (Dr Tim Stevens (LMB, Cambridge))

2016-05-25 10:15: Matching density maps of macromolecular assemblies from Cryo-EM and assessment of fitted atomic models (Dr Agnel Praveen Joseph)

2016-06-01 10:15: TBC (Dr Owen Davies (Newcastle University))

2016-06-15 10:15: Targeting Trehalose and Methylglucose Lipopolysaccharide Pathways of M. tuberculosis (Nupur Verma (Department of Biochemistry, Cambridge))

2016-07-13 10:15: Predicting the impact of natural and disease variants on protein function (Professor Rob Russell (Heidelberg University))

2016-09-28 10:15: Interactive molecular dynamics for improved model building and exploration in structural biology (Dr Tristan Croll (CIMR, Cambridge))

2016-10-10 15:00: Structure and Function of TIFA - A New Player in Immunity and Cancer (Prof Ming-Daw Tsai (Academia Sinica in Taiwan))

2016-10-26 10:15: A computational framework for optimizing combination drug therapies (Dr Michael Lyons (Colorado State University))

2016-11-16 14:30: Phosphoproteomic strategies reveal global impact of kinase inhibitors on regulatory kinase networks and the phosphoproteome (Prof David Litchfield (University of Western Ontario))

2017-01-25 10:15: What's new at PDBe? (Dr Deepti Gupta and Dr John Berrisford (PDBe))

2017-02-28 14:30: Myc and MexR: conformational selection and fuzzy complexes in transcriptional regulation (Prof Maria Sunnerhagen (Linkoping University, Sweden))

2017-03-01 10:15: Computational study of mutations in proteins (Professor Douglas Pires (Centro de Pesquisas René Rachou, FIOCRUZ - Minas Gerais, Brazil))

2017-03-08 10:15: Using Integrative Methods in Structural Biology to Understand Protein Structure (Dr Daniel Saltzberg (University of California, San Francisco))

2017-03-23 10:15: Dynamic interactions and fuzzy structures in protein complexes and higher-order assemblies (Dr Monika Fuxreiter)

2017-03-29 10:15: COSMIC Catalogue of Cancer Mutations and the 3D Proteome (Simon Forbes & Harry Jubb (Sanger Institute, Wellcome Genome Campus))

2017-04-03 10:15: High-Throughput Fragment-Based Drug Discovery at Diamond Synchrotron: Robots can do much of the work to screen in FBDD! (Prof Frank von Delft (Diamond Light Source / Structural Genomics Consortium - Oxford))

2017-05-10 10:15: Rebuilding the HDX-MS Method to Support Integrative Methods in Structural Biology (Dr David Schriemer (University of Calgary, Alberta))

2017-05-24 10:15: Revolutionary Cryo-EM: the Potential  Power to Visualize High Resolution Dynamic Structures (Dr Kai Zhang (LMB))

2017-05-31 10:15: Linking Structural Biology and Clinical Genomics: Purine Nucleotidase in Relapsed Leukemia (Dr. Aleš Hnízda (Academy of Sciences of the Czech Republic, Prague; From 1st June: Department of Biochemistry, University of Cambridge))

2017-10-11 10:15: Signalling through interleukin/interferon receptors: outside and inside of the cell (Dr. Alexander Wlodawer (Chief, Macromolecular Crystallography Laboratory, NCI-Frederick))

2017-12-13 10:15: The simple reason that M. avium subspecies paratuberculosis has been missed as a major human pathogen is that, unknowingly, it's been treated since 1942 (Dr Robert Greenstein (VA Medical Center, Bronx, NY))

2018-01-24 10:30: Human 2-oxoacid-dependent Oxygenases (Dr M. S. Islam (Department of Biochemistry, University of Cambridge))

2018-02-26 10:15: Shortening Tuberculosis Chemotherapies: Elucidating the Molecular genetic programs of persistence of M. tuberculosis (Professor W. Jacobs, Howard Hughes Medical Institute, NY)

2018-03-07 10:15: Mycobacterium Tuberculosis Physiology: The Intricate Interplay between Drug Tolerance and Drug Resistance (Caroline Pule (Faculty of Medicine, Stellenbosch University, South Africa))

2018-03-19 10:15: Not Too Big - Not Too Small: Fragment Antibody Drug Candidates as Alternatives to Antibodies for Solid Tumours (Dr Gokhan Yahioglu (Director of Medicinal Chemistry, Antikor Biopharma Ltd))

2018-03-21 10:30: Using Computational Structure Biology to Study Diseases that cause Major Health Concerns in Brazil (Dr Pedro Torres)

2018-03-28 10:15: Toward the Reconstitution of the Maturation of Okazaki Fragments Multiprotein Complex in Human at the Single Molecule Level (Dr Luay Joudeh (Pellegrini Group))

2018-04-25 10:15: Substrate reduction enabled by structural biology as therapy for metabolic disorders (Dr Gustavo Arruda Bezerra (Structural Genomics Consortium – University of Oxford))

2018-05-09 10:30: Correlative tweezers fluorescence microscopy: one step towards real-time single-molecule biology (Dr Joanna Andrecka (Lumicks))

2018-05-16 10:30: Fragment based inhibition of CK2α (Dr Paul Brear (Hyvonen Group))

2018-05-23 10:30: Solution-based angular measurements of protein structure and conformational change by second-harmonic generation (SHG) (Dr Joshua Salafsky (Founder and CSO, Biodesy Inc, San Francisco))

2018-06-06 10:30: Protein and Peptide Mass Spectrometry Analysis (Dr Anja Andrejeva (Cambridge Centre for Proteomics))

2018-06-20 10:15: Structural studies of a DNA unwinding machine (Dr Laura Spagnolo (University of Glasgow))

2018-06-20 10:15: Architecture of PIKK Kinases and their molecular mechanisms of regulation (Dr Taiana De Oliveira (Astra Zeneca))

2018-10-31 16:00: Protein:protein recognition in the Ubiquitin Proteasome-degradation System (UPS) and Membrane Surface Complexes from the Ras-family (Dr Andrew Byrd (Head of Macromolecular NMR, National Cancer Institute, Maryland))

2018-11-28 10:15: Capturing the 3D Folds of Whole Mammalian Genomes in Single Cells (Dr Tim Stevens (Cell Biology Division, LMB))

2018-12-03 15:00: A Saposin-lipoprotein nanoparticle system for membrane proteins (Dr Jens Frauenfeld (CEO Salipro Biotech, Sweden))

2019-02-20 16:00: tRNA Modifications and Decoding Errors (Professor Eric Westhof (Institut de Biologie Moléculaire et Cellulaire du CNRS, Université de Strasbourg))