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John Skidmore, Alzheimer’s Research UK Cambridge Drug Discovery Institute
Wednesday 21 February 2018, 10:30-11:30
Developing drugs for neurodegeneration and other diseases in academia, industry and in-between
- 👤 Speaker: John Skidmore, Alzheimer’s Research UK Cambridge Drug Discovery Institute
- 📅 Date & Time: Wednesday 21 February 2018, 10:30 - 11:30
- 📍 Venue: Department of Chemistry, Cambridge, Unilever lecture theatre
Abstract
Over recent decades, medicinal chemists have proven to be very efficient at finding small molecules to modulate the activity of enzyme and receptor targets but this has not always led to the development of new drugs. Drawing on examples from industry, academia and the not-for-profit sector, ways in which this gap can be bridged will be explored. Firstly, the importance of expanding the range of druggable targets will be discussed using the example of RAD51 -BRCA2 protein-protein interaction inhibitors. Secondly, the challenge of identifying druggable targets to drive a reduction in the level of the misfolded proteins thought to cause many neurodegenerative diseases will be explored, using examples from the Alzheimer’s Research UK Cambridge Drug Discovery Institute.
Series This talk is part of the Biophysical Seminars series.
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