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Conformational and oligomeric rearrangements control intercellular signalling

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If you have a question about this talk, please contact Robert Jones .

Intercellular communication, orchestrated by cell-surface expressed proteins, is a fundamental aspect of the formation, function and pathology of all tissues and organs. Protein structure, interaction and conformational change determine signalling and adhesion events. Using two target systems with central roles in the formation and maintenance of our nervous system; transmembrane receptors Myelin associated glycoprotein (MAG) and Sortilin, we show how interactions and conformational changes on the cell surface and between cells underlie the molecular mechanisms of signal transduction and adhesion.

This talk is part of the MRC LMB Neurobiology Seminars series.

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