University of Cambridge > Talks.cam > Computational and Systems Biology > A comparison of background correction methods for two-colour microarrays

  Browse A-Z

Log in

University Account External (via Google)

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

A comparison of background correction methods for two-colour microarrays

Download to your calendar using vCal

If you have a question about this talk, please contact Danielle Stretch .

Microarray data must be background corrected to remove the effects of non-specific binding or spatial heterogeneity across the array, however this practice typically causes other problems such as negative corrected intensities and high variability of low intensity log-ratios. In this talk, I will present the results of a comparison of different estimators of background, and various model-based processing methods which aim to overcome these problems. 8 different background correction alternatives are compared, in terms of precision and bias of the resulting gene expression measures, and in terms of their ability to detect differentially expressed genes. Data sets where some independent truth in gene expression is known a priori are used in the comparison. Recommendations on the best methods to use for differential expression analyses of small microarray experiments will be given.

This talk is part of the Computational and Systems Biology series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Computer Laboratory, William Gates Building, LT2 FW26?? Mathematics of John Thompson Conference on Finite Groups and related topics

Other talks

Group Presentation 4 Shining a light on the origin of supermassive black holes with cosmological simulations Proteomics: Expression Analysis and Subcellular Localisation Cambridge Reading Group on Reproduction: Professor Sara Brill Title to be confirmed LMB Seminar - Mechanisms of mRNA packaging and export
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity