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The Biology of Eating

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Abstract: Globally, obesity-associated diseases such as Type 2 diabetes cause over 3 million deaths annually. The rising prevalence of obesity is driven by the consumption of high calorie foods and reduced levels of physical activity, which contribute to a persistent imbalance between energy intake and expenditure leading to weight gain. However, within a given environment, some people are particularly susceptible to severe obesity, whilst others remain thin. In this lecture, I will describe how genetic studies have shaped our understanding of the pathways that regulate eating behaviour and body weight. I will share insights into how the brain regulates behaviours such as eating, that were previously considered to be under voluntary control.

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