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Matteo Molè
Monday 24 May 2021, 14:30-15:30
Morphogenesis of the mouse and human embryo beyond implantation
- 👤 Speaker: Matteo Molè
- 📅 Date & Time: Monday 24 May 2021, 14:30 - 15:30
- 📍 Venue: Online
Abstract
During the transition from pre-implantation to early post-implantation the mammalian embryo undergoes major morphogenetic changes, leading to transformation of the blastocyst into the egg-cylinder or bilaminar disk configuration, in mouse or human respectively. We found that integrin 1 is required during this transition, coordinating morphogenesis and promoting survival of the embryo proper. By single cell RNAseq, we also characterised a sequence of events underlying post-implantation development of the human embryo. We identified a group of cells which may act as an evolutionary-conserved anteriorising signalling centre for the establishment of the anterior-posterior axis prior to gastrulation.
Series This talk is part of the Morphogenesis Seminar Series series.
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