University of Cambridge > Talks.cam > MRC Biostatistics Unit Seminars > BSU Seminar: "Design and Inference for Enrichment Trials with a Continuous Biomarker"

  Browse A-Z

Log in

Googledetails Microsoftdetails

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

BSU Seminar: "Design and Inference for Enrichment Trials with a Continuous Biomarker"

Download to your calendar using vCal

If you have a question about this talk, please contact Alison Quenault .

This will be a hybrid seminar. If you would like to attend virtually, please register for free here - https://us02web.zoom.us/meeting/register/tZErduCprzwiEtQhPshDBMXcqhwlvdZtp_IP

Joint work with Nancy Flournoy, Rosamarie Frieri, and Zhantao Lin

We describe the philosophical approaches to two-stage enrichment designs, in which a benefitting subpopulation is targeted in a second stage, after a first stage identifies the threshold of a predictive, continuous biomarker. The design issue we address is sample size estimation for the first and second stages, and the consequences of poorly estimating the threshold. These design issues are established based on an approach where the two stages are conducted and analyzed separately, and stage two is considered a confirmatory trial. Another approach is to combine the data from the two stages, and we demonstrate how to do that by testing two hypotheses simultaneously with test statistics that (we show) have an asymptotic normal distribution. While a bivariate normal model is used to give insights into the predictive nature of the biomarker, and to visualize some closed-form solutions, in principle other models can certainly be used (but perhaps yield fewer insights). As in many ongoing, long-term research projects, our work probably raises more questions than it answers!

This talk is part of the MRC Biostatistics Unit Seminars series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Automated Chemical Synthesis Enabled by Digital Molecular Technologies (EPSRC CDT) Seminar Room 1, Hopkins Building, Biochemistry Department, Cambridge LR10, Baker Building (South wing).

Other talks

Group Work Talk title TBC Together Now: Cooperation and Collaboration in Social Art Practice Clonal haematopoiesis, early detection and pre-leukemia to leukemia development Early cancer clinical trials Beyond Hubble: Studying the Earliest Galaxies with the James Webb Space Telescope
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity