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Milstein Lecture 2022 - mRNA Cancer Vaccines

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The purpose of a therapeutic cancer vaccine is to instruct the patient’s immune system to recognize and eliminate cancer cells. The origins of using mRNA for delivery of cancer vaccines date back to the 1990s. However, early attempts were hampered by low vaccine potency and lack of clinical activity due to various biological and technologies challenges. This talk will provide an overview on the scientific groundwork, key discoveries, inventions, and technological solutions that have paved the development and clinical application of highly potent, personalized mRNA cancer vaccines, a novel approach that for the first time allows a treatment to be individually tailored to the complex genetic profile of a patient’s tumor.

This talk is part of the MRC LMB Seminar Series series.

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