Abstract

From biological organisation principles to supramolecular biofabrication and tissue engineering

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Living systems have evolved to grow and heal through biological organization principles (BOPs) capable of organizing molecular and cellular building-blocks at multiple size scales. These BOPs emerge from cooperative interactions and chemical networks between multiple components, which allow biological systems to diversify, respond, and optimize. This talk will present our laboratory’s efforts to combine supramolecular events found in nature such as self-assembly, disorder-to-order transitions, or diffusion-reaction processes with engineering processes to design bioinspired materials and devices. I will also describe recent efforts aiming to go beyond “bioinspiration” and into “biocooperation”. I will describe methodologies to develop a) dynamic hydrogels and in vitro models for cancer b) self-assembling fluidic devices and c) regenerative implants.