University of Cambridge > Talks.cam > Seminars on Quantitative Biology @ CRUK Cambridge Institute > OpenFold: Lessons learned and insights gained from rebuilding and retraining AlphaFold2.

  Browse A-Z

Log in

Googledetails Microsoftdetails

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

OpenFold: Lessons learned and insights gained from rebuilding and retraining AlphaFold2.

Download to your calendar using vCal

If you have a question about this talk, please contact Estelle Heather Pepper .

On Zoom Only

AlphaFold2 revolutionized structural biology by accurately predicting protein structures from sequence. Its implementation however (i) lacks the code and data required to train models for new tasks, such as predicting alternate protein conformations or antibody structures, (ii) is unoptimized for commercially available computing hardware, making large-scale prediction campaigns impractical, and (iii) remains poorly understood with respect to how training data and regimen influence accuracy. Here we report OpenFold, an optimized and trainable version of AlphaFold2. We train OpenFold from scratch and demonstrate that it fully reproduces AlphaFold2’s accuracy. By analyzing OpenFold training, we find new relationships between data size/diversity and prediction accuracy and gain insights into how OpenFold learns to fold proteins during its training process.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Scott Polar Research Institute Lecture Theatre se456's list in person & via zoom

Other talks

A Data-Centric Approach to AI Adaptation and Alignment CSAR lecture: 46&: Development of a probiotic that supports the natural removal of forever chemicals from the body Title to be confirmed Animating urbanism: the demotic multiplicities of seeing cities digitally Title TBC CSAR lecture: In a post-Ozempic world, have we cured obesity?
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity