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Studying human oncoproteins beyond cancer: lessons learned from the RAS GTPases

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  • UserPau Castel, NYU School of Medicine
  • ClockTuesday 04 July 2023, 14:00-15:00
  • HouseCRUK CI.

If you have a question about this talk, please contact Ciara Adeniyi-Jones .

Oncoproteins are well-known drivers of cancer and participate in virtually all steps of oncogenic transformation. Among these, RAS oncoproteins are drivers of tumor initiation and progression and therapies targeting these directly or their downstream pathways have resulted in unprecedented clinical benefit in cancer. However, recent advances in genomic medicine have revealed that many of the known RAS oncoproteins and their regulators are also involved in the pathogenesis of a group of congenital disorders termed RASopathies. In these individuals, germline pathogenic variants give rise to phenotypes that can shed light on the physiological function of the proto-oncoprotein. Our laboratory’s research has been focused on understanding the role of RAS oncoproteins in both cancer and congenital disorders. During my talk I will discuss our recent efforts in characterizing a non-classical RAS GT Pase termed RIT1 , which is mutated in both cancer and RASopathies. We have identified a novel mechanism of regulation for this GTPase and have developed unique cellular and animal models to understand the role of RIT1 at the organismal level. Our work provides novel insights into the regulation, function, and pathogenesis of RAS oncoproteins.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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