Abstract

Pineal cysts (PCs) are common. They can be seen in up to a third of MRI scans of adult volunteers. As a rule, PCs are asymptomatic, but when larger, they can be associated with symptoms. These include headaches, visual and other sensory symptoms, impairment of balance, hearing, cognition and sleep. The relationship between patient symptoms and PCs is not well understood. Nevertheless, approximately 90% of patients whose pineal cysts are resected experience improvement of their symptoms and quality of life. In March 2023 we completed recruitment to the first prospective series of surgically treated patients with symptomatic PCs and continue to be the only UK centre that is able to offer such a treatment. Our study offers an opportunity not only to explain the pathophysiology of symptomatic PCs but also contribute to the understanding of the anatomy and function of the tectum and brain more widely.