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Horizonal gene transfer in transmissible cancers

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If you have a question about this talk, please contact Samantha Noel .

Although somatic cell genomes are usually entirely clonally inherited, sporadic exchange of nuclear DNA between cells of an organism by a process of cell fusion, phagocytosis, or through other mechanisms, can occur. This phenomenon has long been noted in the context of cancer, where it could be envisaged that horizontal gene transfer plays a functional role in disease evolution. However, an understanding of the frequency and significance of this process in naturally occurring tumours is lacking. I will describe the results of a screen that searched for horizontal gene transfer in transmissible cancers occurring in dogs and Tasmanian devils.

This talk is part of the Computational and Systems Biology Seminar Series 2023 - 24 series.

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