Abstract

In this talk, I will discuss two applications of biomedical fluid mechanics in urology and regenerative medicine, and present new theoretical models developed alongside complementary experimental approaches. Throughout the talk, I will highlight how the derivation and exploitation of reduced models that retain the essential physics, while remaining tractable, can provide mechanistic insights into these biomedical fluid flows, and discuss how the resulting insights can be exploited to drive new healthcare innovations. The first application will show how a detailed understanding of the fluid mechanics associated with medical devices used to treat kidney stones can be exploited to guide innovations in device operation and design with enhanced mass transport properties. The second application in regenerative medicine considers the complex interplay of cells, biomaterials, and bioreactors and microfluidic systems required for tissue growth, repair and regeneration. I will show how insights into the wealth of fluid mechanics challenges encountered in regenerative medicine, including fluid-structure interactions, reactive multiphase flows, and advective transport, can guide the development of new regenerative medicine therapies and protocols.