University of Cambridge > Talks.cam > Department of Pharmacology Seminar Series > Pharmacology Seminar Series: Dr Florian Merkle, Drug Discovery, Action, and Repurposing in iPSC-derived Neurons

  Browse A-Z

Log in

Googledetails Microsoftdetails

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

Pharmacology Seminar Series: Dr Florian Merkle, Drug Discovery, Action, and Repurposing in iPSC-derived Neurons

Download to your calendar using vCal

If you have a question about this talk, please contact Daniel Paolo Juan .

Dr Florian Merkle

Principal Investigator, Department of Pharmacology, University of Cambridge

Drug Discovery, Action, and Repurposing in iPSC-derived Neurons

The Merkle lab studies rare human brain cell populations that regulate hunger, and whose activity is related to obesity and diabetes. Specifically, they differentiate human pluripotent stem cells (hPSCs) into hypothalamic POMC neurons that suppress appetite, and then characterize how they respond to existing anti-obesity drugs such as semaglutide/Ozempic, as well as using them to discover novel therapeutic strategies. In the past years, we have developed scalable methods to measure the functional activity of POMC neurons using calcium imaging on high-content confocal microscopes, and by measuring their secretion of the appetite-suppressing neuropeptide MSH in a high-throughput assay. We look forward to harnessing these models with our colleagues in Pharmacology as our work moves increasingly toward therapeutic translation.

This talk is part of the Department of Pharmacology Seminar Series series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Wolfson Lecture Theatre & ONLINE - Details to be sent by email Seminar room 11, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus Cambridge, CB2 0SP United Kingdom Average on weekdays: 8764.91304348 kWh

Other talks

Tea and Coffee Break Morning Tea and Coffee An AI-Assisted Proof in Spectral Geometry Title to be confirmed Title to be confirmed Am I a Member? Auditing Private Machine Learning
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity