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Deciphering EMT morphogenetic forces

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Folding is a basic morphogenetic process essential to shape organs and tissues. Apical constriction is often viewed as the main driving force leading to epithelium folding. Consistent with other recent studies, our work highlights the importance of apico-basal forces in epithelium folding, coming either from apoptotic cells or from cells undergoing epithelia-mesenchymal transition (EMT). We are further studying the force generation mechanism taking place during the initial steps of the EMT process, leading to the detachment of the extruding cell.  We are also analyzing how the forces generated during EMT affect cell nucleus and whether and how they contribute to the transcriptional shift observed during this cellular process.

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BAS Seminar Room 1; https://bas-ac-uk.zoom.us/j/93676773793 GS5, Faculty of Education, 184 Hills Road, Cambridge Zoom https://maths-cam-ac-uk.zoom.us/j/95208706709.

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