University of Cambridge > Talks.cam > Seminars on Quantitative Biology @ CRUK Cambridge Institute > Hard numbers—physicochemical models of a mitotic signalling organelle​

  Browse A-Z

Log in

Googledetails Microsoftdetails

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹ️ Information

Hard numbers—physicochemical models of a mitotic signalling organelle​

Download to your calendar using vCal

  • UserKevin A. Janes, Ph.D.​ Departments of Biomedical Engineering and Biochemistry & Molecular Genetics, University of Virginia​
  • ClockTuesday 02 December 2025, 16:00-17:00
  • HouseCRUK CI Lecture Theatre.

If you have a question about this talk, please contact Simona Valeviciute .

Abstract: Cancer is a complex disease that is best tackled by iterations of quantitative experiments and mathematical models at the systems level. Biochemically, obtaining protein copy numbers and binding affinities is laborious, but absolute quantities are powerful to test and refine hypotheses. We have built fully parameterized models that combine physics and chemistry to abstract a key biochemical reaction network that is essential for ensuring the fidelity of mitosis. Disruptions of the network in cancer do not occur by mutation but instead by alterations in protein abundances that change its emergent switch-like detection of proper chromosomal alignment on the metaphase plate. By integrating kinase enzymology with protein-protein interactions and biomolecular condensation on chromatin, we identify surprising stoichiometric constraints and flexibilities for network function. The models support a working hypothesis that a membraneless organelle formed by the chromosomal passenger complex buffers abundance changes to a point that is exceeded periodically by stoichiometrically imbalanced cancers and precancers.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

New Hall Art Exhibition, Murray Edwards College, Huntingdon Road Butterfly Genetics Group Lab Meeting Bateson Room, Department of Genetics, Downing Site

Other talks

Tea and Coffee Break Discovery Investigations: Science, Empire and the Making of the British South Atlantic Afternoon Break Online Causal Inference Seminar Security Cooperation within Government and between Governments Morning Tea and Coffee
 

© 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity