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Local Translation at the Synapse

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An individual neuron in the brain possesses approximately 10,000 synapses, many of which are hundreds of microns away from the cell body, which can process independent streams of information. During synaptic transmission and plasticity, remodeling of the local proteome occurs via the regulated synthesis and degradation of new proteins. I will discuss previous and current studies aimed at understanding how local protein synthesis contributes to synaptic function and plasticity. Using deep-sequencing techniques and bioinformatic approaches, we can now describe the local transcriptome- a large population of previously undetected mRNAs that code for synaptically relevant proteins.

This talk is part of the MRC LMB Seminar Series series.

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