Abstract

CANCER THEME

The Cambridge PhD Training Programme in Chemical Biology & Molecular Medicine will be holding its annual symposium on the Addenbrooke’s site at the Cancer Research UK Cambridge Research Institute on Monday 10th October.

Speakers will include:

TOM HEIGHTMAN (Director of Medicinal Chemistry, Astex) our annual keynote lecture – Epigenetic Drug Discovery

KJ PATEL (MRC Laboratory of Molecular Biology) – Protecting Against the Genotoxic Consequences of Naturally Produced Reactive Aldehydes

STEVE JACKSON (Wellcome Trust/CRUK Gurdon Institute) – Cellular Responses to DNA Damage: Drug Discovery and Drug Evaluation

Plus research updates from the programme’s PhD students:

Developing a Novel Approach Towards “Synthetic Lectins” with the View of Imaging Cancer Cell Glycoproteins (Yelena Wainman)

Genetic Instability and Cancer: Inhibiting Aurora Kinase A and TPX2 Interaction (Matej Janecek)

Designing Novel Bioorthogonal Reactions for the Site-Selective Glycosylation of Proteins (Lily Chan)

DNA Modifications and Epigenetic Processes in Cancer Progression and Metastasis (Martin Bachman)

Fragment Based Design of Inhibitors of the TPX2 -Importin-α Interaction (Rhian Holvey)

Biophysical Evaluation of the Rad51-BRCA2 Protein-Protein Interaction and the Design and Synthesis of Inhibitors (Luca Laraia)

Synthesis and Biological Evaluation of Allosteric Inhibitors of the Motor Protein, HSET (Ciorsdaidh Watts)

New Approaches in Epigenetic Therapy: Non-coding RNA as a Target for Polycomb Inhibition (Liang Wu)

Unravelling Uncinatone: Piecing Together the Clues Towards a Potential Topoisomerase II Inhibitor (Andrew Lewis)

Allosteric Polo-like Kinase 1 Inhibitors: A Fragment-Based Approach (Christopher Stubbs)

Development of Novel Small Molecule Inhibitors of XIAP -Caspase 9 Interactions (Danny Allwood)

Cyclopamine: Inspiration for Novel Inhibitors of the Hedgehog Signalling Pathway (Elliott Bayle)

Ruthenium-based Enzyme Inhibitors: Pioneering a New Generation of Metallodrugs (Simon Page)

There will also be a POSTER SESSION . There is still space to accommodate a few more posters. If you are interested in presenting your relevant research please contact me asap. The symposium is free to attend – but please email rmm32@cam.ac.uk to register ASAP .

See programme website for further details: http://www-medchem.ch.cam.ac.uk/