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Nitric Oxide controls a switch between degenerative and regenerative phases of developmental neuronal remodelling

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Neuronal remodeling is essential to refine neural circuits during normal development of vertebrates and invertebrates. Remodelling often involves axon fragmentation and elimination followed by axon regrowth. How neurons switch between these developmental growth states is mostly unknown. Using the stereotypic remodelling of the Drosophila mushroom body (MB) as a model, we have uncovered a switching mechanism between degenerative axon pruning and axonal regrowth. In my lecture, I will unravel this mechanism which is orchestrated by nitric oxide (NO) levels and executed, at least in part, by two heme-binding nuclear receptors and the TOR pathway.

This talk is part of the MRC LMB Seminar Series series.

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LLT, Department of Plant Sciences, Downing Site, Downing Street, Cambridge Whiston Society Science Talks Social Sciences Committee Room (Free School Lane)

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