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Hunting for viral packaging signals

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If you have a question about this talk, please contact Prof. Julia Gog .

Influenza has a genome split into several segments, and this complicates virus particle assembly as each particle must have one of each of the segments. This means that each of the RNA segments must contain some signal, and that this signal ought to be fairly conserved. Is this enough to go and hunt them down using mathematics? The answer turns out to be yes. However, this required some creativity in algorithm design, drawing inspiration from a number of apparently unrelated problems. This hack seems to work, but leaves some interesting mathematical problems.

This talk is also about the research dynamics itself, and the weird twists and turns that it takes.

This talk is part of the Worms and Bugs series.

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