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SUMMARY:TODAY! “Oscillations in mitochondrial ROS production regulate th
 e early embryonic cell cycle in Xenopus” - Dr Javier Iglesias-Gonzalez\,
  Division of Cell Matrix Biology &amp\; Regenerative Medicine\, Manchester
  University
DTSTART:20180125T160000Z
DTEND:20180125T170000Z
UID:TALK100123@talks.cam.ac.uk
CONTACT:Lyn Dakin
DESCRIPTION:Abstract\nThe ability to repair and regenerate tissues is an e
 ssential process for the survivability and development of the organisms. A
 mphibians excel on these processes and are invaluable models to study the 
 molecular and cellular mechanisms underlying scar free wound healing and t
 issue regeneration. Among these\, we have used the frog\, Xenopus\, as an 
 animal model to study the role of reactive oxygen species (ROS) during the
  early embryonic development and appendage regeneration. Both embryonic de
 velopment and tissue repair/regeneration require cell proliferation\, whic
 h relies on the synchronized mechanisms that regulate the cell cycle [1]. 
 The mitochondrion is the powerhouse of the cell but it is also involved in
  other processes such as cellular signaling and calcium buffering. However
 \, the roles of mtROS during early vertebrate development have remained la
 rgely unknown. For this reason\, our main aim is to understand how the mit
 ochondria\, metabolism and ROS are regulated during early development and 
 tissue regeneration. To achieve this goal we use a combination of biochemi
 cal\, life-imaging and molecular biology techniques. In this sense\, by us
 ing transgenic Xenopus frog embryos expressing the genetically encoded ROS
  indicator HyPer we have recently shown that mtROS is increased after fert
 ilization and that it oscillates during each cell division [2]. These nove
 l results highlight an entanglement between calcium\, metabolism and ROS b
 ut further work is being conducted to understand how these processes are r
 elated to the cell cycle and its relevance for the early development and t
 issue regeneration. \nReferences:\n1.	Pomerening JR (2009) Positive feedba
 ck loops in cell cycle progression. FEBS Lett. 583(21):3388-3396.\n2.	Han 
 Y.\, Ishibashi S.\, Iglesias-Gonzalez J\, Chen Y\, Love\, NR\, Amaya E. (2
 018). Ca2+-Induced Mitochondrial ROS Regulate the Early Embryonic Cell Cyc
 le. Cell Reports 22:218-231.\n\n\n
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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