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SUMMARY:Epigenetic regulation of antibody production and the formation of 
 B cell memory to acute and chronic infections - Dr Kim Good-Jacobson\; Hea
 d\, B cells and Antibody Memory Laboratory\, NHMRC RD Wright Biomedical Ca
 reer Development Fellow\, Biochemistry and Molecular Biology\, Monash Univ
 ersity\, Australia
DTSTART:20180612T120000Z
DTEND:20180612T130000Z
UID:TALK100339@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:The production of high-affinity antibody and immune memory is 
 central to adaptive immunity. Epigenetic mechanisms are emerging as essent
 ial regulatory nodes in antibody production. Alterations in the genomic la
 ndscape that allow or restrict access of transcription factors are critica
 l to enact or repress gene expression programs during cell differentiation
  and are modulated by enzymes. For example\, the histone methyltransferase
 s MLL and Dot1L modulate chromatin to permit transcription\, whereas the t
 wo Polycomb repressive complexes work together to repress gene expression.
  Our recent work has focused on determining the histone modifiers that reg
 ulate B cell differentiation during immune responses and how these regulat
 ory processes may go awry in disease. This presentation will detail the dy
 namic regulation by multiple different epigenetic complexes that is requir
 ed for antibody production and the formation of immunological memory. Furt
 hermore\, our investigation into whether chronic infection alters the geno
 mic landscape in B cells and whether epigenetic regulatory checks are subv
 erted in persisting infections\, will be discussed.\n\nDr. Kim Good-Jacobs
 on leads the B cells and Antibody Memory laboratory at Monash University\,
  investigating chromatin and transcriptional modifications underlying the 
 formation of immune memory. She is a NHMRC Career Development Fellow\, and
  her work has been published in the top general and specialist journals\, 
 such as Science\, Nature Immunology and the Journal of Experimental Medici
 ne. Dr. Jacobson completed her PhD at the Centenary and Garvan Institutes 
 in 2007\, followed by postdoctoral training at Yale University\, where she
  revealed a novel role for the inhibitory receptor PD-1 in humoral respons
 es. She returned to Australia in 2010 to the Walter and Eliza Hall Institu
 te\, where she made key insights into how histone modifications regulate B
  cell memory\, as well as the essential requirement for the oncogene c-Myb
  in the migration of long-lived plasma cells to their survival niche. She 
 was a 2016 Victorian Young Tall Poppy Science Award recipient\, currently 
 serves as Treasurer for the Australasian Society for Immunology and writes
  for The Conversation.\n
LOCATION:Babraham - The Cambridge Building\; Kings Hedges Room
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