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SUMMARY:Transcriptional control of pluripotent stem cell fate by the Nucle
 osome Remodelling and Deacetylation (NuRD) complex - Dr Brian Hendrich\; C
 ambridge Stem Cell Institute\, University of Cambridge
DTSTART:20180228T130000Z
DTEND:20180228T140000Z
UID:TALK100348@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Chromatin remodelling complexes play essential roles in metazo
 an development through widespread control of gene expression. The genetic 
 requirements for many of the components of such complexes have been descri
 bed\, and their biochemical activities characterised in vitro\, yet the pr
 ecise molecular mechanisms by which chromatin remodellers impact transcrip
 tional regulation in vivo remain ill-defined. In my lab we have been study
 ing the Nucleosome Remodelling and Deacetylation (NuRD) complex in mouse E
 S cells. Functionally\, NuRD is required for pluripotent cells to properly
  undergo lineage commitment both in vitro and in vivo\, and mouse embryos 
 lacking key NuRD components die in peri-implantation stages. Despite these
  profound developmental defects\, NuRD deficiency in ES cells results in o
 nly moderate gene expression changes\, with the majority of genes changing
  by less than two-fold. These small transcriptional changes nevertheless r
 esult in a profound phenotype of developmental failure. I will present or 
 latest results in defining molecularly how the enzymatic activities of NuR
 D fine-tune transcription in mouse ES cells\, and how biochemical dissecti
 on of NuRD can be used to define NuRD function during lineage commitment. 
LOCATION:Babraham - The Cambridge Building\; Kings Hedges Room
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