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SUMMARY:Babraham Lecture - Cellular responses to DNA damage: from mechanis
 tic insights to applications in cancer therapy - Prof. Steven Jackson\; We
 llcome Trust/Cancer Research UK Gurdon Institute\, University of Cambridge
DTSTART:20180911T130000Z
DTEND:20180911T140000Z
UID:TALK101062@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:As DNA is frequently subject to a wide array of molecularly di
 stinct forms of damage\, life has evolved multiple DNA repair and associat
 ed processes\, collectively termed the DNA-damage response (DDR). The impo
 rtance of DDR mechanisms is underlined by their deregulation or loss causi
 ng cancer and various human genetic disorders whose pathologies include st
 em-cell exhaustion\, developmental defects\, infertility\, immune-deficien
 cy\, neuro-degeneration\, cancer predisposition and/or premature ageing. W
 ork in my laboratory aims to decipher DDR mechanisms\, particularly those 
 triggered by DNA double-strand breaks. In this talk\, I will describe some
  of our recent work using CRISPR-Cas9 genetic screens and ensuing mechanis
 tic studies to identify new DDR factors/regulators and then define their f
 unctions. I will also explain how such work is identifying new avenues for
  anti-cancer therapy and is helping us understand how cancer cells can evo
 lve resistance to therapeutic agents.
LOCATION:Babraham - The Cambridge Building\; Petersfield Lecture Theatre
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