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SUMMARY:Going 3D: expansion\, differentiation and migration of adult human
  stem cells in 3D cell culture systems. - Darius Widera\, Lecturer in Stem
  Cell biology and Regenerative Medicine\, University of Reading.
DTSTART:20180209T150000Z
DTEND:20180209T160000Z
UID:TALK101170@talks.cam.ac.uk
CONTACT:Vanessa Blake
DESCRIPTION:Since the early days\, ex vivo mammalian cell culture has been
  conducted on flat two-dimensional (2D) glass or polystyrene surfaces. Alt
 hough 2D cell culture is still widely used\, it is known to result in unna
 tural cell polarity and morphology in addition to lacking the three-dimens
 ional extracellular matrix. These drawback are especially evident if the c
 ultivated cells are stem cells. In this context\, 2D cultivation is known 
 to interfere with stem cell proliferation and to alter cell migration and 
 differentiation capability. In this talk\, different approaches to 3D cult
 ivation\, differentiation and assessment of migration will be discussed. I
 n particular\, biocompatible natural and synthetic scaffolds for cultivati
 on of adult human neural crest-derived stem cells and human mesenchymal st
 em cells of different origin will be presented. Moreover\, different appli
 cations of 3D scaffolds within modern regenerative medicine will be presen
 ted. 
LOCATION:Lecture Theatre 3\, Department of Chemical Engineering and Biotec
 hnology\, West Cambridge Site
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