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SUMMARY:Pathways of Amyloid Aggregation - Dr Birgit Strodel\, Forschungsze
 ntrum Jülich
DTSTART:20181024T131500Z
DTEND:20181024T141500Z
UID:TALK101176@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:A major cause for cellular toxicity involved in the onset of s
 everal neurodegenerative diseases is the aberrant aggregation of proteins 
 into toxic oligomers and eventually inert fibrils. In the case of Alzheime
 r's disease\, the main aggregating peptide is the amyloid β-peptide (Aβ)
 . We aim to understand the thermodynamics and kinetics of the Aβ aggregat
 ion process\, from isolated monomers into oligomers and under varying exte
 rnal conditions known to play a role during the development of Alzheimer
 ’s disease\, such as the presence of metal ions and lipid bilayers\, or 
 changes in pH. To this end\, we use all-atom molecular dynamics simulation
 s to explore the aggregation process and describe the aggregation pathways
  using transition networks calculated from the simulation data.\n
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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