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SUMMARY:Interkinetic nuclear migration as a stochastic process in the zebr
 afish retina - Anne Herrmann (University of Cambridge)
DTSTART:20180215T130000Z
DTEND:20180215T140000Z
UID:TALK101362@talks.cam.ac.uk
CONTACT:Anne Herrmann
DESCRIPTION:Recent work shows that some of the complexity of vertebrate ti
 ssues can be understood when stochastic processes are assumed to play a ro
 le in development. For example\, in the zebrafish retina both the varying 
 numbers of offspring from a single progenitor cell as well as the distribu
 tions of final cell fates have been explained using simple probabilistic m
 odels. We focus on interkinetic nuclear migration (IKNM)\, a type of nucle
 ar movement that has been suggested to be involved in the regulation of re
 tina cell fates and itself exhibits features of a stochastic process. Comb
 ining in vivo light sheet microscopy and mathematical modelling\, we devel
 op a quantitative description of IKNM. This description will enable an und
 erstanding of the involvement of IKNM in retina development regulation. 
LOCATION:MR11\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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