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SUMMARY:The 6th Annual Sir John Walker Lecture\, 'Genomics approaches to m
 itochondrial physiology and disease' - Vamsi K Mootha MD\, HHMI and Harvar
 d Medical School\, USA
DTSTART:20180222T163000Z
DTEND:20180222T173000Z
UID:TALK101401@talks.cam.ac.uk
CONTACT:Penny Peck
DESCRIPTION:I will present our lab's efforts to utilize genomics approache
 s to achieve a holistic and mechanistic understanding of mitochondria in h
 ealth and disease.  This talk will be organized into three sections.  Firs
 t\, I will present our lab's efforts employing computational genomics to s
 ystematically identify all of the molecular components of the mitochondria
 l calcium uniporter.  Having identified all of these components\, an ongoi
 ng challenge lies in achieving a mechanistic understanding of how these co
 mponents operate together.  Second\, I will review our past efforts utiliz
 ing genomic sequencing to investigate the molecular genetic basis of mitoc
 hondrial disease\, and more recent work aimed at understanding their molec
 ular pathogenesis.  Third\, I will present our latest efforts to utilize g
 enome-scale genetic screening to identify new therapeutic strategies for a
 lleviating mitochondrial disease.
LOCATION:Max Perutz Lecture Theatre\, MRC Laboratory of Molecular Biology\
 , Cambridge Biomedical Campus
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