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SUMMARY:Time-dependent regulation of memory retrieval by hippocampal clock
  - Professor Satoshi Kida - Department of Bioscience\, Tokyo University of
  Agriculture (TUA)
DTSTART:20180309T130000Z
DTEND:20180309T140000Z
UID:TALK101563@talks.cam.ac.uk
CONTACT:Lorraine Coulson
DESCRIPTION:Cognitive performance in people varies according to time-of-da
 y\, with memory retrieval declining in the late afternoon-early evening. H
 owever\, functional roles of local brain circadian clocks in memory perfor
 mance remains unclear. Here we show that hippocampal clock controlled by t
 he circadian-dependent transcription factor BMAL1 regulates time-of-day re
 trieval profile. Inducible transgenic dominant negative BMAL1 (dnBMAL1) ex
 pression in mouse forebrain or hippocampus disrupted retrieval of hippocam
 pal memories at Zeitgeber Time 8-12\, independently of retention delay\, e
 ncoding time and Zeitgeber entrainment cue. This altered retrieval profile
  was associated with downregulation of hippocampal Dopamine-cAMP signaling
  in dnBMAL1 mice. These changes included decreases in Dopamine Receptors a
 nd GluA1-S845 phosphorylation by PKA. Consistently\, pharmacological activ
 ation of cAMP-signals rescued impaired retrieval efficiency in dnBMAL1 mic
 e. Importantly\, GluA1 S845A knock-in mice showed similar retrieval defici
 ts with dnBMAL1 mice. Our findings suggest mechanisms underlying regulatio
 n of retrieval by hippocampal clock through D1/5R-cAMP-PKA-mediated GluA1 
 phosphorylation.
LOCATION:Kenneth Craik Room\, Craik Marshall Building\, Downing Site\, Cam
 bridge
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