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SUMMARY:Optical Coherence Tomography for Pharmaceutical Coatings  and Copi
 ng with the Raw Data Nightmare - Patrick Wahl\, Research Center Pharmaceut
 ical Engineering GmbH\, Graz\, Austria
DTSTART:20180316T140000Z
DTEND:20180316T153000Z
UID:TALK102622@talks.cam.ac.uk
CONTACT:Vanessa Blake
DESCRIPTION:This talk presents a novel tool for in-line monitoring of phar
 maceutical spray coating processes for tablets and pellets by means of an 
 OSeeT industrial optical coherence tomography (OCT) system. Coating thickn
 ess as a function of time can be measured for tablets in a drum coater and
  for pellets in a fluid bed coater. OCT can also be of value for more exot
 ic applications like core-skin co-extrusion products among others.\n\nThe 
 presentation will cover two main pillars: (1) introduction to the OCT tech
 nology and its applications and (2) a discussion about raw data definition
  and storage in high-speed imaging applications. \n\nFirst\, the physical 
 principles behind OCT will be explained shortly\, explaining why OCT does 
 not need chemometric modelling. Further\, a reference target for OCT will 
 be presented\, which can be used for routine calibration checks. Two metho
 d comparison studies show the correctness of the OCT results and contrast 
 it to common off-line and in-line coating thickness measurements. This par
 t will be concluded with application data from tablet and pellet coating.\
 n\nOCT and other high-speed imaging methods\, like near-infrared chemical 
 imaging or image based particle size methods\, share a common challenge. T
 he sensor data generated during continuous measurement quickly hits the te
 rabyte regions\, which could become an IT administrator's nightmare. OCT s
 ensor data is about 1 terabyte per hour\, while the results (information o
 n coating thicknesses) take up less than 1 megabyte per hour. Regulators d
 emand the storage of raw data. Thus\, the definition of raw data needs to 
 be somewhere in between sensor data and results only and needs to be wisel
 y chosen. The preferred definition of raw data will be given and justified
 \, as well as its impact on storage requirements.\n
LOCATION:Lecture Theatre 1\, Department of Chemical Engineering and Biotec
 hnology\, West Cambridge Site
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