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SUMMARY:Miniguts: A System to Understand Intestinal Pathologies - Dr. Fern
 anda Schreiber (Sanger) &amp\; Dr. Maria Duque (Sanger)
DTSTART:20180321T183000Z
DTEND:20180321T200000Z
UID:TALK103111@talks.cam.ac.uk
CONTACT:Postdoc Masterclass
DESCRIPTION:Animal and cellular models are extensively used to understand 
 biological processes.\nHowever\, most of these models are inadequate in re
 creating human tissues\, hampering the\ntranslation of knowledge we get fr
 om them. Organoids are a novel in vitro system generated\nfrom human prima
 ry tissues and recapitulating their architecture and cellular composition.
 \nMiniguts (enteric organoids) are 3D cell clusters generated from gut tis
 sue showing similar\ncharacteristics and function to the gut. In this mast
 erclass\, we will give an overview of\norganoids and how this system can b
 e used to study human intestinal diseases from noninfectious \nand infecti
 ous origin. Specifically\, utilizing human miniguts we study the role of\n
 Interleukin-22 and the microbiota in the pathogenesis of IBD. We also use 
 mouse miniguts to\nunderstand early interactions of the intestinal epithel
 ia with whipworms\, which are parasitic\nworms causing Trichuriasis\, a ne
 glected tropical disease.
LOCATION: Postdoc Centre\, Biomedical Campus\, Bay 13\, Hills Road\, Cambr
 idge CB2 0SP
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