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SUMMARY:The Genetic Code -Insights into its Origin and Evolution - Hiroyuk
 i Oshikane\, Laboratory of Molecular Biology
DTSTART:20080131T131500Z
DTEND:20080131T134500Z
UID:TALK10324@talks.cam.ac.uk
CONTACT:Emanuel Busch
DESCRIPTION:Proteins are composed of 20 kinds of amino acids. Aminoacyl tR
 NA\, in which an amino acid is covalently bound to 3’ end of tRNA\, carr
 ies the “right” amino acid onto the ribosome where translation occurs.
  Commonly\, it is thought that at least 20 sets of aminoacyl-tRNA syntheta
 ses (aaRS) are required for accurate protein biosynthesis. But none of arc
 haea and bacterial organelle has perfect sets of canonical aaRSs\; that is
 \, they lack glutaminyl-tRNA synthetase (GlnRS)\, asparaginyl-tRNA synthet
 ase (AsnRS)\, lysyl-tRNA synthetase (LysRS)\, and cysteinyl-tRNA synthetas
 e (CysRS) in methanogenic archaea. It would be noteworthy that archaea\, w
 hich is thought to be the origin of life or close to it\, has such an “o
 dd” translation system.\nI would like to introduce the unique translatio
 n system in archaea and talk about the mysterious origin of genetic code b
 ased on recent biochemical and structural evidence.\n\n<References>\nAmbro
 gelly\, A.\, et al. “Natural expansion of the genetic code.” (2007) Na
 ture Chemical Biology 1 29-35\nOshikane H.\, et al. “Structural basis of
  RNA-dependent recruitment of glutamine to the genetic code.” (2006) Sci
 ence 312 1950-1954\nTumbla\, D.L.\, et al. “Domain-specific recruitment 
 of amide amino acids for protein synthesis.” (2000) Nature 407 106-110\n
 \n
LOCATION:Entertaining Room\, Darwin College
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