BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Hypothalamic control of body weight: the role of protein degradati
 on systems in a high-fat diet-induced obesity model - Dr Mariana Portovedo
 \; University of Campinas (Unicamp)\, Brazil 
DTSTART:20180510T120000Z
DTEND:20180510T130000Z
UID:TALK103495@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Protein degradation systems are critical to the maintenance of
  cellular proteostasis. In the central nervous system (CNS) impairment of 
 the ubiquitin-proteasome system and autophagy are linked to neuronal dysfu
 nction in many neurodegenerative diseases. The hypothalamus is one of the 
 main areas of the CNS that is responsible for the control of food intake a
 nd neuronal dysfunction in this area is one of the hallmarks of obesity pa
 thophysiology. In this talk I will lead you through the physiology of the 
 hypothalamic control of food intake and will present data showing that dys
 regulation of protein degradation systems in the hypothalamus is connected
  to hypothalamic dysfunction in high-fat diet-induced obese mice.
LOCATION:Babraham - The Cambridge Building\; Kings Hedges Room
END:VEVENT
END:VCALENDAR