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SUMMARY:Computational modeling of the CD8 T cell immune response: How math
 ematical models can provide insights on differentiation and heterogeneity?
   - Dr Fabien Crauste\; Institut Camille Jordan\, University of Lyon\, Fra
 nce 
DTSTART:20180719T120000Z
DTEND:20180719T130000Z
UID:TALK103501@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Identification of a differentiation pathway common to all CD8 
 T cells and enabling to characterize functionnal properties during acute i
 nfections generated intense discussions over the past five years. I will p
 resent a differentiation pathway based on Mki67 and Bcl2 expressions\, obt
 ained by combining immunological data\, bioinformatics and mathematical mo
 deling\, in collaboration with immunologists colleagues in Lyon (Dr. Marve
 l's team at the International Center for Research in Infectiology). I will
  then introduce a computational multiscale model of the CD8 T cell respons
 e that includes coupled descriptions of both molecular and cellular dynami
 cs and I will show that it represents an original tool for investigating t
 he influence of early molecular events on the long-term cellular dynamics 
 in silico. Finally\, I will conclude with preliminary results on the role 
 of molecular and cellular heterogeneity in the process of immune memory ge
 neration\, based on the previously mentioned multiscale model.
LOCATION:Babraham - The Cambridge Building\; Kings Hedges Room
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