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SUMMARY:Cafe Synthetique: Next Generation Synthetic Biologists - Speaker t
 o be confirmed
DTSTART:20180521T170000Z
DTEND:20180521T190000Z
UID:TALK103510@talks.cam.ac.uk
CONTACT:Alexandra Ting
DESCRIPTION:This month will feature talks from post-grads working on excit
 ing projects related to synthetic biology.\n\nJarrod Shilts - Masters stud
 ent at the Sanger Institute\n\n'Modulating the Mutation Potential of Synth
 etic DNA'\nOur capacity to engineer biological systems is contingent on th
 e predictability and stability of the genetic parts used to control those 
 systems. However\, natural processes of mutation and evolution pose a fund
 amental limit to the long-term predictability of engineered \nbehavior. In
  this talk\, I will introduce a novel approach to rationally re-design syn
 thetic DNA sequences to have lower mutagenic potential\, thus mitigating t
 he risk of unintended changes that may compromise the function or safety o
 f genetically-encoded parts. In line with the theme of “next generation 
 synthetic biologists”\, I will also highlight how this work exemplifies 
 the potential for student-led lab spaces to contribute to the rapidly-adva
 ncing field of synthetic biology. \n\nOm Patange - PhD student in James Lo
 cke's group at the Sainsbury Laboratory\n\n'Escherichia coli can survive s
 tress by noisy growth modulation'\nE coli is a popular and well characteri
 zed chassis for synthetic biology. Yet\, there is much left to learn about
  this organism. In this talk I will show how E coli use stochastic gene ex
 pression and growth rate modulation to hedge their bets against stressful 
 events.\n\nVáclav Beránek - PhD student in Jason Chin's group at the MRC
  LMB\n\n'Expanding the genetic code in mammalian cells'\nNature makes prot
 eins from a limited set of building blocks - the 20 canonical amino acids.
  Expanding this set by amino acids with new chemical and physical properti
 es allows researchers to manipulate and study proteins in an unprecedented
  way. When extended to mammalian cells\, genetic code expansion allows res
 earchers to label\, probe and control proteins in their native context - p
 roviding unique insights into basic biological questions - and serves as a
  tool to engineer new therapeutics.\n\nCafé Synthetique is the monthly me
 etup for the Cambridge synthetic biology community with informal talks\, d
 iscussion and pub snacks. Kindly sponsored by Cambridge Consultants.
LOCATION:Panton Arms 43 Panton Street CB2 1HL\, Cambridge
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