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SUMMARY:Babraham Lecture - Pathology from the Molecular Scale on Up - Prof
 essor Garry Nolan\; Microbiology &amp\; Immunology - Baxter Laboratory\, S
 tanford University\, California\, USA 
DTSTART:20180724T130000Z
DTEND:20180724T140000Z
UID:TALK103555@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:High parameter single cell analysis has driven deep understand
 ing of immune processes.  Using a next-generation single-cell “mass cyto
 metry” platform we quantify surface and cytokine or drug responsive indi
 ces of kinase target with 45 or more parameter analyses (e.g. 45 antibodie
 s\, viability\, nucleic acid content\, and relative cell size).  Similarly
 \, we have developed two advanced technologies termed MIBI and CODEX that 
 enable deep phenotyping of solid tissue in both fresh frozen and FFPE form
 ats (50 – 100 markers).   Collectively\, the systems allows for subcellu
 lar analysis from the 70nm resolution scale to whole tissue in 3D.\nI will
  present evidence of deep internal order in immune functionality demonstra
 ting that differentiation and immune activities have evolved with a defina
 ble “shape”.  Further\, specific cellular neighborhoods of immune cell
 s are now definable with unique abilities to affect cellular phenotypes—
 and these neighborhoods alter in various cancer disease states.   In addit
 ion to cancer\, these shapes and neighborhoods are altered during immune a
 ction and “imprinted” during\, and after\, pathogen attack\, traumatic
  injury\, or auto-immune disease.  Hierarchies of functionally defined tra
 ns-cellular modules are observed that can be used for mechanistic and clin
 ical insights in cancer and immune therapies.\n
LOCATION:Babraham - The Cambridge Building - Petersfield Lecture Theatre
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