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SUMMARY:Live response of Xenopus ciliated ectoderm to exogenous flow - Fra
 ncesco Boselli (University of Cambridge)
DTSTART:20180412T120000Z
DTEND:20180412T130000Z
UID:TALK103867@talks.cam.ac.uk
CONTACT:Anne Herrmann
DESCRIPTION:During embryonic development\, the orientation of motile cilia
  is established in part through the action of mechanical forces\, but the 
 underling mechanisms remain unclear. A working hypothesis is that hydrodyn
 amic torques that act on the cilia are transmitted to the basal bodies\, w
 hich then reorient through viscoelastic or active processes. A direct test
  of this mechanism has remained outstanding.     \n\nThe skin of the Afric
 an clawed frog (Xenopus laevis) larvae is covered by ciliated cells very s
 imilar to those on humans\, and provides an accessible model system to stu
 dy the development of ciliated tissues. We have developed a protocol for l
 ive imaging of Xenopus ectoderm explants within a flow chamber. Our experi
 ments show that  exogenous flow do not solely leads to cilia rotation\, bu
 t also to changes in the relative position of the basal bodies\, cell shap
 e and cell intercalation.  \n\nCilia reorientation is then expected to be 
 driven not only by hydrodynamic torques\, but also by an overall remodelli
 ng of the ciliated tissue in response to the applied shear and pressure.  
LOCATION:MR11\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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