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SUMMARY:Mathematical models for cell migration with real-time cell cycle d
 ynamics -  Matthew Simpson (Queensland University of Technology)
DTSTART:20180426T120000Z
DTEND:20180426T130000Z
UID:TALK103873@talks.cam.ac.uk
CONTACT:Anne Herrmann
DESCRIPTION:Fluorescent ubiquitination-based cell cycle indicator\, known 
 as FUCCI\, enables the visualisation of the G1 and S/G2/M cell cycle phase
 s of individual cells. FUCCI consists of two fluorescent probes\, so that 
 cells in the G1 phase fluoresce red and cells in the S/G2/M phase fluoresc
 e green. FUCCI reveals real-time information about cell cycle dynamics of 
 individual cells\, and can be used to explore how the cell cycle relates t
 o the location of individual cells\, local cell density\, and different ce
 llular microenvironments. In particular\, FUCCI is used in experimental st
 udies examining cell migration\, such as malignant invasion and wound heal
 ing. Here we present simple mathematical models which can describe cell mi
 gration and cell cycle dynamics as indicated by FUCCI.  We present experim
 ental data from scratch assays using FUCCI-transduced melanoma cells\, and
  show that the predictions of spatial and temporal patterns of cell densit
 y in the experiments can be described by our mathematical model. We obtain
  numerical solutions of both the model\, which can take the form of travel
 ling waves. These solutions are mathematically interesting because they ar
 e a combination of moving wavefronts and moving pulses. We derive and conf
 irm a simple analytical expression for the minimum wave speed\, and conclu
 de by outlining future directions of our work in this area.
LOCATION:MR12\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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