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SUMMARY:Understanding the molecular basis for drug and nutrient transport 
 across the membrane.  - Professor Simon Newstead\, University of Oxford
DTSTART:20181016T140000Z
DTEND:20181016T150000Z
UID:TALK104011@talks.cam.ac.uk
CONTACT:72232
DESCRIPTION:Membrane transporters have a major impact on the pharmacokinet
 ic properties of many orally administered drug molecules\, being responsib
 le for their intestinal uptake and subsequent organ distribution. There is
  now a growing momentum in the field of drug development to use membrane t
 ransporters as ‘Trojan horses’ to improve the uptake of drug molecules
  that previously had poor absorption or excretion properties\; so called p
 rodrug strategies. Of particular interest is the human peptide transporter
 \, PepT1 (SLC15A1) which is expressed in our GI tract\, kidney and blood b
 rain barrier membranes. Several FDA approved drugs have been modified\, th
 rough the addition of L-Valine\, to use PepT1 to improve their intestinal 
 uptake and kidney retention. However\, the molecular basis for how peptide
  transporters  recognize drug molecules\, how they mimic physiological pep
 tides and a basic pharmacophore model have remained elusive. In this talk 
 I will present our recent work on peptide\, amino acid and nucleotide suga
 r transporters and discuss how these systems advance our understanding of 
 drug and nutrient transport and regulation within the cell. 
LOCATION:Sackler Lecture Theatre (Level 7) Wellcome Trust/MRC Building\, C
 ambridge Biomedical Campus
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