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SUMMARY:Bob Groves - I'm Glovin' It and Alex Routh - How do LEA proteins o
 perate? - Alexander F. Routh\, BP Institute and Bob Groves\, BP Institute 
 visitor
DTSTART:20180517T103000Z
DTEND:20180517T113000Z
UID:TALK104911@talks.cam.ac.uk
CONTACT:Catherine Pearson
DESCRIPTION:Bob Groves - I'm Glovin' It\nAqueous polymer dispersions are v
 ersatile materials used in the production of many familiar items\, includi
 ng paints\, tyres\, adhesive and carpets.  Another member of this family i
 s the humble rubber glove\, made in billions per year.\n\nIn this talk\, t
 he nature and production of synthetic polymer dispersions is explained.  R
 easons are suggested why one such dispersion\, known as nitrile latex\, ha
 s become widely used to make rubber gloves\, including the ubiquitous purp
 le glove.  Glove manufacture is discussed and some recent advances in unde
 rstanding its details are presented. Current work in BPI\, aimed at reduci
 ng the environmental impact of glove production\, is described.\n\nAlex Ro
 uth - How do LEA Proteins Operate?\nSome organisms can survive freezing an
 d thawing. One example is a nematode and how they survive is not known. It
  is hypothesised that the nematodes exude intrinsically disordered protein
 s and these protect globular proteins from denaturating during freezing.\n
 We grow nematode intrinsically disordered proteins in e-coli and show that
  it does indeed protect a model globular protein (pig heart citrate syntha
 se) through many rounds of freeze-thaw. Using multiple techniques we find 
 no interaction between the two proteins.\n\nWe deuterated the intrinsicall
 y disordered protein and using neutron reflectivity we show how the IDP pr
 eferentially adsorbs at the air-water interface. This stops the citrate sy
 nthase from unfolding at the hydrophobic interface.\n\n
LOCATION:Open Plan Area\, BP Institute\, Madingley Rise CB3 0EZ
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