BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Neutrophils in the regulation of inflammation - Dr Venizelos Papay
 annopoulos\; The Francis Crick Institute\, London
DTSTART:20181210T130000Z
DTEND:20181210T140000Z
UID:TALK105187@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Neutrophils are essential phagocytes of the innate immune syst
 em. They engage pathogens via degranulation\, phagocytosis and the release
  of extracellular web-like structures called neutrophil extracellular trap
 s (NETs). Recent findings highlight novel immunomodulatory roles for these
  cells\, particularly in the regulation of inflammation. Under sterile con
 ditions\, NET release promotes inflammation and atherosclerosis by turning
  on pro-inflammatory cytokine expression in lesion-associated macrophages.
  Moreover\, during infection neutrophils regulate their own recruitment co
 nditionally by adjusting their cytokine expression according to the size o
 f the microbes they encounter. The differential localization of reactive o
 xygen species (ROS) generated in response to microbes of different size pl
 ays a critical role in regulating interleukin-1β expression and the forma
 tion of neutrophil clusters required to clear large microbes. Finally\, ne
 utrophil derived ROS can regulate function of other cells such as T cells 
 and suppress tumour growth. 
LOCATION:Babraham - The Cambridge Building\; Kings Hedges Room
END:VEVENT
END:VCALENDAR