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SUMMARY:Babraham Distinguished Lecture - Selective autophagy receptors and
  LIR-ATG8 interactions in autophagy - Prof. Terje Johansen\; The Arctic Un
 iversity of Norway
DTSTART:20190523T130000Z
DTEND:20190523T140000Z
UID:TALK105196@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Selective autophagy\, the selective degradation of macromolecu
 les or organelles by autophagy\, is a crucial quality control process vita
 l for cellular homeostasis and prevention of disease. Cargoes to be degrad
 ed are recognized by selective autophagy receptors\, like the Sequestosome
  1/p62-Like Receptors (SLRs). p62/SQSTM1 and other SLRs couple cargo to th
 e forming autophagosomes\, called phagophores\, via interactions with the 
 ATG8 family of proteins through a short motif in the autophagy receptors\,
  the LIR motif. ATG8 family proteins are also involved in scaffolding the 
 autophagosome nucleation machinery. We have found that both the ULK1/2- an
 d class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) complexes 
 as well as ATG4B rely on GABARAP subfamily ATG8 proteins for membrane scaf
 folding interactions. \n The targeted clearance of surplus\, damaged or dy
 sfunctional mitochondria by autophagy (mitophagy) is one of the most impor
 tant selective autophagy processes. SLRs are involved in mitophagy in addi
 tion to the membrane-bound mitophagy receptors. In a collaborative effort 
 between our group and the group of Anne Simonsen we have found that the mi
 tochondrial matrix proteins NIPSNAP1 (4-Nitrophenylphosphatase domain and 
 non-neuronal SNAP25-like protein homolog 1) and NIPSNAP2 accumulate on the
  mitochondrial surface upon mitochondrial depolarization. There they recru
 it SLRs and ATG8 proteins\, thereby functioning as “eat-me” signals fo
 r mitophagy. In another study\, we have uncovered a novel mitophagy recept
 or that collaborates with the archetypical SLR\, p62/SQSTM1 in the turnove
 r of a subset of mitochondrial membrane proteins by piecemeal basal mitoph
 agy.
LOCATION:Babraham - The Cambridge Building\; Petersfield Lecture Theatre
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