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SUMMARY:Nanostructures Prepared from Self-Assembly of Pillararene-Based Ma
 crocyclic Amphiphiles and Supramolecular Amphiphiles - Professor Feihe Hua
 ng\, Zhejiang University
DTSTART:20180724T100000Z
DTEND:20180724T110000Z
UID:TALK105649@talks.cam.ac.uk
CONTACT:Lingtao Kong
DESCRIPTION:Inspired by the natural phospholipid bilayer nanostructure\, w
 hich is an important part of the cell membrane\, various functional groups
  were introduced into pillararene-based macrocyclic amphiphiles\, endowing
  their self-assemblies with interesting applications.1\,2 For example\, we
  designed and synthesized an amphiphilic pillar[5]arene containing five a
 mino groups as the hydrophilic head and five alkyl chains as the hydropho
 bic tail.1a It self-assembled into well-defined nanovesicles under neutra
 l conditions in 1 minute\, and gradually transformed into microtubes after
  standing for 4 months. The nanovesicles were used in the controlled relea
 se of small molecules and the microtubes could be used to adsorb TNT. Simi
 larly\, “sweet nanotubes” were obtained from self-assembly of a sugar-
 functionalized macrocyclic amphiphile.2b These sweet nanotubes were utiliz
 ed as excellent cell glues to agglutinate and inhibit the motility of path
 ogenic cells E. coli. \n\nPillararene-based host-guest interactions were e
 mployed to construct a series of supramolecular amphiphiles not only in or
 ganic solvent but also in water.3 For example\, we constructed a novel sup
 ramolecular amphiphile based on a pillar[6]arene and an azobenzene-contain
 ing guest in an organic solvent\, which underwent a photoresponsive thread
 ing-dethreading switch upon UV and visible light irradiation due to the tr
 ans−cis photoisomerization of the guest\, accompanied by disassembly and
  assembly of the corresponding aggregates.3a \n
LOCATION:Wolfson Lecture Theatre\, Department of Chemistry
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