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SUMMARY:Information Efficacy of a Dynamic Synapse - Mehrdad Salmasi (Ludwi
 g-Maximilians-University Munich)
DTSTART:20180503T143000Z
DTEND:20180503T153000Z
UID:TALK105673@talks.cam.ac.uk
CONTACT:Rodrigo Echeveste
DESCRIPTION:One of the functional consequences of short-term synaptic depr
 ession in neuronal transmission is the modulation of the synaptic informat
 ion transfer rate. To quantify the effect of synaptic depression on the in
 formation rate\, we model a release site by a binary asymmetric channel wi
 th a memory of release outcomes. The model distinguishes between spike-evo
 ked and spontaneous releases\, both of which depend on the history of the 
 site's activity: the release probabilities depress whenever a vesicle is r
 eleased and recover back during quiescent intervals. First we derive the m
 utual information rate of a single release site and show that depression c
 an increase the information rate\, provided that the spontaneous release i
 s depressed more than the spike-evoked release. Then we calculate the info
 rmation rate of a depressing synapse with multiple release sites and deter
 mine the number of release sites that the synapse requires to optimally tr
 ansfer information. Finally\, we take into account the synaptic energy con
 sumption of the neuron and analyze the trade-off between the rate of infor
 mation transmission and energy expenditure of the neuron. 
LOCATION:Cambridge University Engineering Department\, CBL\, BE4-38 (http:
 //learning.eng.cam.ac.uk/Public/Directions)
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