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SUMMARY:mTOR signaling and cancer: basic science meets translational resea
 rch - Professor Michael Hall\, University of Basel
DTSTART:20180529T150000Z
DTEND:20180529T160000Z
UID:TALK105985@talks.cam.ac.uk
CONTACT:Paula Murphy
DESCRIPTION:Cancer is a major health problem due to the failure of current
  therapies to effectively eradicate the disease.  Extensive research over 
 decades has led to the development of therapies that target cancer-specifi
 c signaling pathways.  However\, tumors escape such therapies by activatin
 g compensatory signaling pathways\, a process referred to as 'evasive resi
 stance'.  The identities of the alternative signaling pathways and the fun
 ctional interconnections that underlie evasive resistance remain widely un
 known.  We integrate clinical\, molecular\, and computational sciences to 
 understand the signaling defects that enable tumors to evade therapy.  Wit
 hin the framework of rigorously designed clinical studies\, hepatocellular
  carcinoma (HCC) tissue is isolated before therapy\, during treatment\, or
  at the time of tumor progression.  The tumor tissue is obtained by needle
  biopsy and immediately snap frozen to preserve in vivo tumor properties. 
  High- and low-throughput experimental and computational methods are then 
 applied to determine the underlying signaling defects.  This endeavor will
  elucidate mechanisms of evasive resistance and may ultimately improve can
 cer diagnosis\, treatment and clinical outcome.  Recent progress in this a
 mbitious project and a related study with an mTOR-driven mouse model for H
 CC will be described. 
LOCATION:Max Perutz Lecture Theatre\, MRC LMB
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