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SUMMARY:Identifying genes involved in sense organ formation in Drosophila 
 - Sebastian Cachero\, Division of Biomedical Sciences\, University of Edin
 burgh
DTSTART:20080205T160000Z
DTEND:20080205T164500Z
UID:TALK10608@talks.cam.ac.uk
CONTACT:Gregory Jefferis
DESCRIPTION:Proneural proteins are transcription factors that occupy the h
 ighest  position in the genetic network that drives sense organ formation.
  One  of the central questions in the field is how the identity of the  pr
 oneural protein is linked to aspects of terminal differentiation. In  orde
 r to address this issue\, a method combining fluorescent activated  cell s
 orting and gene expression microarrays was developed and used to  identify
  the transcriptional profiles of sense organ precursors and  their progeny
 . Interestingly\, among the genes we identified there is a  group of diffe
 rentiation genes\, raising the possibility that proneural  proteins direct
 ly control aspects of terminal differentiation. Another  finding was the p
 ossible involvement in sense organ formation of a  microRNA gene.
LOCATION:MRC LMB: Neurobiology Division Seminar Room (Level 2)
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